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Best Microsoft Defender for Office 365 Alternatives & Competitors in 2026 | CybersecTools

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Microsoft Defender for Office 365

Best Microsoft Defender for Office 365 Alternatives & Competitors in 2026

Top picks: ConnectWise Email Security, Vade (Hornetsecurity) 365 Total Protection, Cisco Secure Email Threat Defense — plus 45 more compared.

Microsoft Defender for Office 365 Alternatives and Competitors

Microsoft Defender for Office 365 is a commercial Email Security Platforms tool developed by Microsoft. Security professionals most commonly compare it with . All 48 alternatives are matched by shared capabilities, tags, and NIST CSF 2.0 coverage.

ConnectWise Email Security

, Vade (Hornetsecurity) 365 Total Protection

, Cisco Secure Email Threat Defense

, Hornetsecurity 365 Total Protection

, and ESET Cloud Office Security

Data verified May 2026

View Microsoft Defender for Office 365 All Email Security Compare Stacks Market Map Explore All Tools

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Top Microsoft Defender for Office 365 Alternatives and Competitors at a Glance

A closer look at the 8 most relevant alternatives and competitors to Microsoft Defender for Office 365, including their key features and shared capabilities.

ConnectWise Email Security

Commercial

Email Security Platforms

Email security platform with AI threat detection, BEC protection, and DLP

Key features: AI-powered threat detection and analysis, Business email compromise (BEC) protection with identity analysis, Data loss prevention with content inspection and policy controls, Phishing and ransomware blocking, Click-time URL sandboxing

View ConnectWise Email Security|ConnectWise Email Security alternatives|Compare ConnectWise Email Security

Vade (Hornetsecurity) 365 Total Protection

Commercial

Email Security Platforms

AI-powered email security platform for Microsoft 365 with backup & compliance.

Key features: AI-powered email threat detection and filtering, Phishing, ransomware, BEC, and malware blocking, Link and attachment scanning, Automated email backup, Regulatory compliance management

View Vade (Hornetsecurity) 365 Total Protection|Vade (Hornetsecurity) 365 Total Protection alternatives|Compare Vade (Hornetsecurity) 365 Total Protection

Cisco Secure Email Threat Defense

Commercial

Email Security Platforms

Email threat protection for Microsoft 365 with advanced detection capabilities

Key features: Advanced threat detection for known, emerging, and targeted threats, Malicious technique identification with business risk context, Real-time threat search and remediation, Searchable threat telemetry and categorization, Vulnerability assessment by organizational unit

View Cisco Secure Email Threat Defense|Cisco Secure Email Threat Defense alternatives|Compare Cisco Secure Email Threat Defense

Hornetsecurity 365 Total Protection

Commercial

Email Security Platforms

Comprehensive M365 security suite with email protection, backup, and compliance

Key features: Spam and malware filtering, Advanced threat protection with sandboxing and URL rewriting, Business email compromise detection, Automated email encryption, Email archiving

View Hornetsecurity 365 Total Protection|Hornetsecurity 365 Total Protection alternatives|Compare Hornetsecurity 365 Total Protection

ESET Cloud Office Security

Commercial

Email Security Platforms

Cloud email security for Microsoft 365 and Google Workspace applications

Key features: Spam filtering, Anti-malware scanning, Anti-phishing protection, Antispoofing protection, Homoglyph protection

View ESET Cloud Office Security|ESET Cloud Office Security alternatives|Compare ESET Cloud Office Security

Bitdefender GravityZone Extended Email Security

Commercial

Email Security Platforms

Cloud-native email security platform with SEG and API-based protection

Key features: Pre-delivery and post-delivery email protection, Secure Email Gateway (SEG) and API-based deployment options, Business Email Compromise (BEC) and impersonation detection, Multi-layered threat detection for known and unknown threats, SPF and DMARC email authentication support

View Bitdefender GravityZone Extended Email Security|Bitdefender GravityZone Extended Email Security alternatives|Compare Bitdefender GravityZone Extended Email Security

Broadcom Symantec Email Security

Commercial

Email Security Platforms

Enterprise email security platform for cloud and on-premise deployments

Key features: Multilayered defense against ransomware, spear phishing, and BEC attacks, Cloud-based and on-premises deployment options, Cloud-based sandboxing for advanced threat detection, Click-time URL protection, Office 365 clawback and remediation

View Broadcom Symantec Email Security|Broadcom Symantec Email Security alternatives|Compare Broadcom Symantec Email Security

OPSWAT MetaDefender Email Security

Commercial

Email Security Platforms

Email security platform protecting against phishing, malware, and exploits

Key features: Multiscanning with up to 30 anti-malware engines for on-premises deployments, Deep Content Disarm and Reconstruction (CDR) for 180+ file types, Real-time anti-phishing with time-of-click link reputation analysis, Real-time adaptive sandbox with 7-second analysis, Data loss prevention supporting 110+ file types with automatic redaction

View OPSWAT MetaDefender Email Security|OPSWAT MetaDefender Email Security alternatives|Compare OPSWAT MetaDefender Email Security

All 48 Alternatives & Competitors to Microsoft Defender for Office 365

Compare

ConnectWise Email Security

Email security platform with AI threat detection, BEC protection, and DLP

Email Security Platforms

Compare

Vade (Hornetsecurity) 365 Total Protection

AI-powered email security platform for Microsoft 365 with backup & compliance.

Email Security Platforms

Compare

Cisco Secure Email Threat Defense

Email threat protection for Microsoft 365 with advanced detection capabilities

Email Security Platforms

Compare

Hornetsecurity 365 Total Protection

Comprehensive M365 security suite with email protection, backup, and compliance

Email Security Platforms

Compare

ESET Cloud Office Security

Cloud email security for Microsoft 365 and Google Workspace applications

Email Security Platforms

Compare

Bitdefender GravityZone Extended Email Security

Cloud-native email security platform with SEG and API-based protection

Email Security Platforms

Compare

Broadcom Symantec Email Security

Enterprise email security platform for cloud and on-premise deployments

Email Security Platforms

Compare

OPSWAT MetaDefender Email Security

Email security platform protecting against phishing, malware, and exploits

Email Security Platforms

Compare

TitanHQ Cybersecurity Bundles

Bundled cybersecurity solutions for MSPs and end users with email protection

Email Security Platforms

Compare

VIPRE Integrated Email Security (IES)

Email security platform for Microsoft 365 with AI-based threat detection

Email Security Platforms

Compare

Mimecast Collaboration Threat Protection

Secures Microsoft Teams, SharePoint & OneDrive from malware and phishing

Email Security Platforms

Compare

API-based email security platform for Microsoft 365 environments

Email Security Platforms

Compare

KnowBe4 Cloud Email Security

AI-driven email security platform for Microsoft 365 inbound/outbound threats

Email Security Platforms

Compare

Vircom Email Security

Email security platform enhanced with multi-tenant mgmt & automation tools

Email Security Platforms

Compare

Abnormal Security Cloud-based email security platform

AI-powered email security platform protecting against phishing, BEC, and ATO

Email Security Platforms

Compare

GLIMPS Email Security for M365

AI-based email security for M365 with phishing, BEC & malware detection.

Email Security Platforms

Compare

Unified AI-powered cybersecurity & cyber insurance platform for SMBs.

Email Security Platforms

Compare

Fortinet FortiMail Email Security

AI-powered email security platform protecting against phishing, BEC, and ATO

Email Security Platforms

Compare

Cellopoint Cloud Email Security Solution

Cloud-based email security platform protecting against phishing, ransomware, BEC

Email Security Platforms

Compare

Email security platform with phishing/BEC protection and MDR/XDR integration

Email Security Platforms

Compare

odix FileWallTM for Microsoft 365

File-based threat protection for Microsoft 365 using CDR technology

Email Security Platforms

Compare

Mimecast Advanced Email Security

Email security platform protecting M365 & Google Workspace from threats

Email Security Platforms

Compare

Trustifi AI Powered Email Security

AI-powered email security platform for threat detection and compliance

Email Security Platforms

Compare

Proofpoint Threat Protection

Email security platform with AI-based threat detection and DLP capabilities

Email Security Platforms

Compare

Egress Intelligent Email Security

Cloud email security platform for inbound/outbound threat detection & DLP

Email Security Platforms

Compare

Infonaligy Proofpoint Email Security

Managed Proofpoint email security service for phishing & BEC protection.

Email Security Platforms

Compare

SourcetekIT Email Security Service

Managed email security service for Office 365 using Cisco's platform.

Email Security Platforms

Compare

TitanHQ Security Bundles

Tiered cybersecurity bundles combining email, DNS, backup & SAT.

Email Security Platforms

Compare

SpamTitan for Office 365

Email security layer for M365 with anti-phishing, sandboxing, and DLP.

Email Security Platforms

Compare

Cloudflare Cloud Email Security

Cloudflare Cloud Email Security is a cloud-based email protection service that safeguards organizations against phishing, malware, spam, and other email-borne threats through integrated threat detection and prevention capabilities.

Email Security Platforms

Compare

INKY Behavioral Email Security Platform

Behavioral email security platform protecting inbound, outbound, and internal mail

Email Security Platforms

Compare

TrustLayer Mail

Email security platform with inline threat protection and compliant archiving

Email Security Platforms

Compare

SorbSecurity Cloud Email Security

Cloud-based email security platform protecting against phishing & ransomware

Email Security Platforms

Compare

GreatHorn Email Security

Cloud-native email security platform for phishing detection and response

Email Security Platforms

Compare

Zivver Secure Business Email

All-in-one email security platform for threat protection and compliance

Email Security Platforms

Compare

MX Layer Email Security

Cloud-based email security platform with AI-powered threat detection

Email Security Platforms

Compare

xorlab Email Security

AI-driven email security platform for detecting advanced email threats

Email Security Platforms

Compare

Trend Micro Trend Vision One™

AI-powered email and collaboration security platform for threat detection

Email Security Platforms

Compare

AnubisNetworks Email Security

Email security platform protecting against fraud, malware, and spam threats

Email Security Platforms

Compare

ESET Mail Security

Email security for Microsoft Exchange servers with anti-spam and anti-malware

Email Security Platforms

Compare

Bitdefender GravityZone Security for Exchange

Email security for Microsoft Exchange servers with antispam and antimalware.

Email Security Platforms

Compare

Darktrace Email Security

AI-powered email security platform detecting threats across email and messaging

Email Security Platforms

Compare

InSAT Security Inbox

Centralized platform for reporting, analyzing, and responding to email threats

Email Security Platforms

Compare

Cybersentriq MX Email Threat Protection

MX-based email security platform using AI to block spam, phishing & malware

Email Security Platforms

Compare

ThreatDown Email Security

AI-powered email security platform for phishing and BEC protection

Email Security Platforms

Compare

IRONSCALES Adaptive AI Email Security

AI-powered email security platform with behavioral detection and automation

Email Security Platforms

Compare

Kaseya 365 Advanced Threat Protection

ATP solution for SaaS & email with AI-driven detection & auto-response

Email Security Platforms

Compare

Blaze Networks Blaze Screen

Managed email filtering service with threat detection and spam prevention

Email Security Platforms

Also compare alternatives to:

ConnectWise Email Security alternatives Vade (Hornetsecurity) 365 Total Protection alternatives Cisco Secure Email Threat Defense alternatives Hornetsecurity 365 Total Protection alternatives ESET Cloud Office Security alternatives Bitdefender GravityZone Extended Email Security alternatives Broadcom Symantec Email Security alternatives OPSWAT MetaDefender Email Security alternatives TitanHQ Cybersecurity Bundles alternatives VIPRE Integrated Email Security (IES) alternatives Mimecast Collaboration Threat Protection alternatives Mesh 365 alternatives

Compare Microsoft Defender for Office 365 with:

Microsoft Defender for Office 365 vs ConnectWise Email Security Microsoft Defender for Office 365 vs Vade (Hornetsecurity) 365 Total Protection Microsoft Defender for Office 365 vs Cisco Secure Email Threat Defense Microsoft Defender for Office 365 vs Hornetsecurity 365 Total Protection Microsoft Defender for Office 365 vs ESET Cloud Office Security Microsoft Defender for Office 365 vs Bitdefender GravityZone Extended Email Security Microsoft Defender for Office 365 vs Broadcom Symantec Email Security Microsoft Defender for Office 365 vs OPSWAT MetaDefender Email Security

Microsoft Defender for Office 365 Alternatives FAQ

Common questions security professionals ask when evaluating alternatives and competitors to Microsoft Defender for Office 365.

What are the best alternatives to Microsoft Defender for Office 365?

The most popular alternatives to Microsoft Defender for Office 365 include ConnectWise Email Security, Vade (Hornetsecurity) 365 Total Protection, Cisco Secure Email Threat Defense, Hornetsecurity 365 Total Protection, and ESET Cloud Office Security. These Email Security Platforms tools offer similar capabilities and are frequently compared by security professionals evaluating their options.

How many alternatives to Microsoft Defender for Office 365 are available?

Is Microsoft Defender for Office 365 free or commercial?

What type of tool is Microsoft Defender for Office 365?

Have more questions? Browse our categories or search for specific tools.

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