The closest Microsoft Defender for Office 365 alternatives are Fortra Email Security & Anti-Phishing, Cisco Secure Email Threat Defense and KnowBe4 Cloud Email Security. Picking a Microsoft Defender for Office 365 alternative comes down to fit: Email Security Platforms coverage, your environment, your integrations and your budget. So each option below shows what it covers, how it deploys, its pricing model and the company behind it.
42 alternativesClosest matches: Fortra Email Security & Anti-Phishing, Cisco Secure Email Threat Defense, KnowBe4 Cloud Email SecurityPage updated Nov 2026
The product
Microsoft Defender for Office 365
by Microsoft
Email and collaboration security for Microsoft 365 environments
Microsoft Defender for Office 365 is a commercial Email Security Platforms solution made by Microsoft. The closest matches by shared tags and NIST CSF 2.0 coverage are Fortra Email Security & Anti-Phishing, Cisco Secure Email Threat Defense, KnowBe4 Cloud Email Security, ConnectWise Email Security, and ID Agent Graphus. All 42 alternatives on this page are ranked the same way.
These 8 solutions overlap most with Microsoft Defender for Office 365. Each row says what the product does and, when the overlap is big enough, which capabilities it shares.
Email security platform protecting against phishing, BEC, and data loss
Key features: DMARC email authentication and enforcement, Business email compromise detection, Spear phishing protection, Account takeover detection, Data loss prevention for sensitive data
Email security platform protecting against phishing, BEC, and data loss
Email threat protection for Microsoft 365 with advanced detection capabilities
AI-driven email security platform for Microsoft 365 inbound/outbound threats
Email security platform with AI threat detection, BEC protection, and DLP
AI-powered anti-phishing platform for Microsoft 365 & Google Workspace.
AI-powered email security platform protecting against phishing, BEC, and ATO
Cloud-based email security platform protecting against phishing, ransomware, BEC
Email security platform protecting M365 & Google Workspace from threats
AI-powered email security operations platform for automated threat triage
Cloud email security for Microsoft 365 and Google Workspace applications
Cloud-native email security platform with SEG and API-based protection
Enterprise email security platform for cloud and on-premise deployments
Email security platform protecting against phishing, malware, and exploits
Email security platform for Microsoft 365 with AI-based threat detection
ATP solution for SaaS & email with AI-driven detection & auto-response
Email security platform enhanced with multi-tenant mgmt & automation tools
AI-based email security for M365 with phishing, BEC & malware detection.
Agentic AI email security platform that investigates emails pre-delivery.
Cloud security platform for M365 covering email, backup, and awareness.
Behavioral email security platform protecting inbound, outbound, and internal mail
Email security platform with phishing/BEC protection and MDR/XDR integration
Email security platform with inline threat protection and compliant archiving
Cloud-native email security platform for phishing detection and response
AI-powered email security platform for threat detection and compliance
Email security platform with AI-based threat detection and DLP capabilities
AI-powered email security platform detecting threats across email and messaging
Bundled cybersecurity solutions for MSPs and end users with email protection
AI-powered email security platform with behavioral detection and automation
Managed Proofpoint email security service for phishing & BEC protection.
Tiered cybersecurity bundles combining email, DNS, backup & SAT.
Email gateway that blocks spam, phishing and malware before inbox delivery, made
Cloudflare Cloud Email Security is a cloud-based email protection service that safeguards organizations against phishing, malware, spam, and other email-borne threats through integrated threat detection and prevention capabilities.
Cloud-based email security platform protecting against phishing & ransomware
All-in-one email security platform for threat protection and compliance
Cloud-based email security platform with AI-powered threat detection
AI-driven email security platform for detecting advanced email threats
AI-powered email and collaboration security platform for threat detection
Email security platform protecting against fraud, malware, and spam threats
Cloud workspace security platform for email, files, and account protection
AI-powered DMARC monitoring and email authentication security platform
Common questions when weighing alternatives to Microsoft Defender for Office 365.
The closest matches to Microsoft Defender for Office 365 by shared tags and NIST CSF 2.0 coverage are Fortra Email Security & Anti-Phishing, Cisco Secure Email Threat Defense, KnowBe4 Cloud Email Security, ConnectWise Email Security, and ID Agent Graphus. All of them are Email Security Platforms products.
This page shows 42 alternatives to Microsoft Defender for Office 365, all in the Email Security Platforms category. Each one is matched on shared tags and NIST CSF 2.0 areas, and the closest matches rank first.
Microsoft Defender for Office 365 is a commercial Email Security Platforms product. It needs a paid license or subscription. Only commercial alternatives are listed here. Free and open source products are under /free.
Microsoft Defender for Office 365 is a Email Security Platforms product in the Email & Messaging Security category. You can compare it with the 42 other Email Security Platforms products on this page.
View Fortra Email Security & Anti-PhishingFortra Email Security & Anti-Phishing alternativesMicrosoft Defender for Office 365 vs Fortra Email Security & Anti-Phishing
Email threat protection for Microsoft 365 with advanced detection capabilities
Key features: 9 listed. See them on the Cisco Secure Email Threat Defense page.
View Cisco Secure Email Threat DefenseCisco Secure Email Threat Defense alternativesMicrosoft Defender for Office 365 vs Cisco Secure Email Threat Defense
AI-driven email security platform for Microsoft 365 inbound/outbound threats
Key features: 10 listed. See them on the KnowBe4 Cloud Email Security page.
View KnowBe4 Cloud Email SecurityKnowBe4 Cloud Email Security alternativesMicrosoft Defender for Office 365 vs KnowBe4 Cloud Email Security
Email security platform with AI threat detection, BEC protection, and DLP
Key features: 10 listed. See them on the ConnectWise Email Security page.
View ConnectWise Email SecurityConnectWise Email Security alternativesMicrosoft Defender for Office 365 vs ConnectWise Email Security
AI-powered anti-phishing platform for Microsoft 365 & Google Workspace.
Key features: 10 listed. See them on the ID Agent Graphus page.
View ID Agent GraphusID Agent Graphus alternativesMicrosoft Defender for Office 365 vs ID Agent Graphus
AI-powered email security platform protecting against phishing, BEC, and ATO
Key features: 10 listed. See them on the Fortinet FortiMail Email and Workspace Security page.
View Fortinet FortiMail Email and Workspace SecurityFortinet FortiMail Email and Workspace Security alternativesMicrosoft Defender for Office 365 vs Fortinet FortiMail Email and Workspace Security
Cloud-based email security platform protecting against phishing, ransomware, BEC
Key features: 8 listed. See them on the Cellopoint Cloud Email Security Solution page.
View Cellopoint Cloud Email Security SolutionCellopoint Cloud Email Security Solution alternativesMicrosoft Defender for Office 365 vs Cellopoint Cloud Email Security Solution
Email security platform protecting M365 & Google Workspace from threats
Key features: 10 listed. See them on the Mimecast Advanced Email Security page.
View Mimecast Advanced Email SecurityMimecast Advanced Email Security alternativesMicrosoft Defender for Office 365 vs Mimecast Advanced Email Security
Need the answer fast? Best Email Security Solutions for Business picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more.See the shortlist