The closest Cisco Secure Email Threat Defense alternatives are Fortra Email Security & Anti-Phishing, Ocean Agentic Email Security Platform and Microsoft Defender for Office 365. Picking a Cisco Secure Email Threat Defense alternative comes down to fit: Email Security Platforms coverage, your environment, your integrations and your budget. So each option below shows what it covers, how it deploys, its pricing model and the company behind it.
43 alternativesClosest matches: Fortra Email Security & Anti-Phishing, Ocean Agentic Email Security Platform, Microsoft Defender for Office 365Page updated Nov 2026
The product
Cisco Secure Email Threat Defense
by Cisco
Email threat protection for Microsoft 365 with advanced detection capabilities
Need the answer fast? Best Email Security Solutions for Business picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more.See the shortlist
Cisco Secure Email Threat Defense is a commercial Email Security Platforms solution made by Cisco. The closest matches by shared tags and NIST CSF 2.0 coverage are Fortra Email Security & Anti-Phishing, Ocean Agentic Email Security Platform, Microsoft Defender for Office 365, NoSpamProxy Protection, and Fortinet FortiMail Email and Workspace Security. All 43 alternatives on this page are ranked the same way.
These 8 solutions overlap most with Cisco Secure Email Threat Defense. Each row says what the product does and, when the overlap is big enough, which capabilities it shares.
Email security platform protecting against phishing, BEC, and data loss
Key features: DMARC email authentication and enforcement, Business email compromise detection, Spear phishing protection, Account takeover detection, Data loss prevention for sensitive data
Email security platform protecting against phishing, BEC, and data loss
Agentic AI email security platform that investigates emails pre-delivery.
Email and collaboration security for Microsoft 365 environments
Email gateway that blocks spam, phishing and malware before inbox delivery, made
AI-powered email security platform protecting against phishing, BEC, and ATO
Cloud-based email security platform protecting against phishing, ransomware, BEC
Email security platform protecting M365 & Google Workspace from threats
Cloud email security for Microsoft 365 and Google Workspace applications
Cloud-native email security platform with SEG and API-based protection
Email security platform protecting against phishing, malware, and exploits
Email security platform for Microsoft 365 with AI-based threat detection
AI-driven email security platform for Microsoft 365 inbound/outbound threats
Email security platform with AI threat detection, BEC protection, and DLP
AI-based email security for M365 with phishing, BEC & malware detection.
AI-powered anti-phishing platform for Microsoft 365 & Google Workspace.
Email and messaging security tool that detects phishing, malware, and targeted threats
Email security platform with inline threat protection and compliant archiving
Enterprise email security platform for cloud and on-premise deployments
AI-powered email security platform detecting threats across email and messaging
AI-powered email security platform with behavioral detection and automation
ATP solution for SaaS & email with AI-driven detection & auto-response
Email security platform enhanced with multi-tenant mgmt & automation tools
Email security layer for M365 with anti-phishing, sandboxing, and DLP.
Cloud security platform for M365 covering email, backup, and awareness.
Cloudflare Cloud Email Security is a cloud-based email protection service that safeguards organizations against phishing, malware, spam, and other email-borne threats through integrated threat detection and prevention capabilities.
Behavioral email security platform protecting inbound, outbound, and internal mail
Email security platform with phishing/BEC protection and MDR/XDR integration
Cloud-based email security platform protecting against phishing & ransomware
Cloud-native email security platform for phishing detection and response
AI-powered email security platform for threat detection and compliance
Cloud-based email security platform with AI-powered threat detection
AI-driven email security platform for detecting advanced email threats
AI-powered email and collaboration security platform for threat detection
Email security platform with AI-based threat detection and DLP capabilities
Email security platform protecting against fraud, malware, and spam threats
AI-powered email security platform detecting advanced threats via behavioral analysis
Cloud workspace security platform for email, files, and account protection
AI-powered DMARC monitoring and email authentication security platform
Bundled cybersecurity solutions for MSPs and end users with email protection
AI-powered email security platform with agentic automation and detection
MX-based email security platform using AI to block spam, phishing & malware
Common questions when weighing alternatives to Cisco Secure Email Threat Defense.
The closest matches to Cisco Secure Email Threat Defense by shared tags and NIST CSF 2.0 coverage are Fortra Email Security & Anti-Phishing, Ocean Agentic Email Security Platform, Microsoft Defender for Office 365, NoSpamProxy Protection, and Fortinet FortiMail Email and Workspace Security. All of them are Email Security Platforms products.
This page shows 43 alternatives to Cisco Secure Email Threat Defense, all in the Email Security Platforms category. Each one is matched on shared tags and NIST CSF 2.0 areas, and the closest matches rank first.
Cisco Secure Email Threat Defense is a commercial Email Security Platforms product. It needs a paid license or subscription. Only commercial alternatives are listed here. Free and open source products are under /free.
Cisco Secure Email Threat Defense is a Email Security Platforms product in the Email & Messaging Security category. You can compare it with the 43 other Email Security Platforms products on this page.
View Fortra Email Security & Anti-PhishingFortra Email Security & Anti-Phishing alternativesCisco Secure Email Threat Defense vs Fortra Email Security & Anti-Phishing
Agentic AI email security platform that investigates emails pre-delivery.
Key features: 10 listed. See them on the Ocean Agentic Email Security Platform page.
View Ocean Agentic Email Security PlatformOcean Agentic Email Security Platform alternativesCisco Secure Email Threat Defense vs Ocean Agentic Email Security Platform
Email and collaboration security for Microsoft 365 environments
Key features: 10 listed. See them on the Microsoft Defender for Office 365 page.
View Microsoft Defender for Office 365Microsoft Defender for Office 365 alternativesCisco Secure Email Threat Defense vs Microsoft Defender for Office 365
Email gateway that blocks spam, phishing and malware before inbox delivery, made
Key features: 10 listed. See them on the NoSpamProxy Protection page.
View NoSpamProxy ProtectionNoSpamProxy Protection alternativesCisco Secure Email Threat Defense vs NoSpamProxy Protection
AI-powered email security platform protecting against phishing, BEC, and ATO
Key features: 10 listed. See them on the Fortinet FortiMail Email and Workspace Security page.
View Fortinet FortiMail Email and Workspace SecurityFortinet FortiMail Email and Workspace Security alternativesCisco Secure Email Threat Defense vs Fortinet FortiMail Email and Workspace Security
Cloud-based email security platform protecting against phishing, ransomware, BEC
Key features: 8 listed. See them on the Cellopoint Cloud Email Security Solution page.
View Cellopoint Cloud Email Security SolutionCellopoint Cloud Email Security Solution alternativesCisco Secure Email Threat Defense vs Cellopoint Cloud Email Security Solution
Email security platform protecting M365 & Google Workspace from threats
Key features: 10 listed. See them on the Mimecast Advanced Email Security page.
View Mimecast Advanced Email SecurityMimecast Advanced Email Security alternativesCisco Secure Email Threat Defense vs Mimecast Advanced Email Security
Cloud email security for Microsoft 365 and Google Workspace applications
Key features: 10 listed. See them on the ESET Cloud Office Security page.
View ESET Cloud Office SecurityESET Cloud Office Security alternativesCisco Secure Email Threat Defense vs ESET Cloud Office Security