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Best Cisco Secure Email Threat Defense Alternatives & Competitors in 2026 | CybersecTools

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Cisco Secure Email Threat Defense

Best Cisco Secure Email Threat Defense Alternatives & Competitors in 2026

Top picks: Microsoft Defender for Office 365, Abnormal Security Cloud-based email security platform, Vade (Hornetsecurity) 365 Total Protection — plus 45 more compared.

Cisco Secure Email Threat Defense Alternatives and Competitors

Cisco Secure Email Threat Defense is a commercial tool developed by Cisco. Security professionals most commonly compare it with . All 48 alternatives are matched by shared capabilities, tags, and NIST CSF 2.0 coverage.

Email Security Platforms

Microsoft Defender for Office 365

, Abnormal Security Cloud-based email security platform

, Vade (Hornetsecurity) 365 Total Protection

, Fortinet FortiMail Email Security

, and Cellopoint Cloud Email Security Solution

Data verified May 2026

View Cisco Secure Email Threat Defense All Email Security Compare Stacks Market Map Explore All Tools

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Top Cisco Secure Email Threat Defense Alternatives and Competitors at a Glance

A closer look at the 8 most relevant alternatives and competitors to Cisco Secure Email Threat Defense, including their key features and shared capabilities.

Microsoft Defender for Office 365

Commercial

Email Security Platforms

Email and collaboration security for Microsoft 365 environments

Key features: AI-powered sentiment analysis for email filtering, Inline protection against malicious links and attachments in Outlook and Teams, Real-time detonation of attachments and links, Automated BEC attack disruption with user disabling and device isolation, Post-delivery removal of malicious emails

View Microsoft Defender for Office 365|Microsoft Defender for Office 365 alternatives|Compare Microsoft Defender for Office 365

Abnormal Security Cloud-based email security platform

Commercial

Email Security Platforms

AI-powered email security platform protecting against phishing, BEC, and ATO

Key features: Behavioral AI-based detection of email attacks, Protection against phishing and business email compromise, Account takeover detection and remediation, Zero-day attack detection, API-based deployment

View Abnormal Security Cloud-based email security platform|Abnormal Security Cloud-based email security platform alternatives|Compare Abnormal Security Cloud-based email security platform

Vade (Hornetsecurity) 365 Total Protection

Commercial

Email Security Platforms

AI-powered email security platform for Microsoft 365 with backup & compliance.

Key features: AI-powered email threat detection and filtering, Phishing, ransomware, BEC, and malware blocking, Link and attachment scanning, Automated email backup, Regulatory compliance management

View Vade (Hornetsecurity) 365 Total Protection|Vade (Hornetsecurity) 365 Total Protection alternatives|Compare Vade (Hornetsecurity) 365 Total Protection

Fortinet FortiMail Email Security

Commercial

Email Security Platforms

AI-powered email security platform protecting against phishing, BEC, and ATO

Key features: AI-powered threat detection using ML and LLM, Multi-layered email scanning with heuristics and optical recognition, Inbound and outbound email protection, Business email compromise and account takeover prevention, Data loss prevention with email encryption

View Fortinet FortiMail Email Security|Fortinet FortiMail Email Security alternatives|Compare Fortinet FortiMail Email Security

Cellopoint Cloud Email Security Solution

Commercial

Email Security Platforms

Cloud-based email security platform protecting against phishing, ransomware, BEC

Key features: AI and machine learning-based threat detection, Phishing protection, Ransomware protection, Business email compromise (BEC) protection, Advanced persistent threat (APT) detection

View Cellopoint Cloud Email Security Solution|Cellopoint Cloud Email Security Solution alternatives|Compare Cellopoint Cloud Email Security Solution

Mimecast Advanced Email Security

Commercial

Email Security Platforms

Email security platform protecting M365 & Google Workspace from threats

Key features: AI and machine learning-based threat detection, Social graphing for anomaly detection, Sandboxing for malware analysis, URL on-click protection, Computer vision for brand impersonation detection

View Mimecast Advanced Email Security|Mimecast Advanced Email Security alternatives|Compare Mimecast Advanced Email Security

ESET Cloud Office Security

Commercial

Email Security Platforms

Cloud email security for Microsoft 365 and Google Workspace applications

Key features: Spam filtering, Anti-malware scanning, Anti-phishing protection, Antispoofing protection, Homoglyph protection

View ESET Cloud Office Security|ESET Cloud Office Security alternatives|Compare ESET Cloud Office Security

Bitdefender GravityZone Extended Email Security

Commercial

Email Security Platforms

Cloud-native email security platform with SEG and API-based protection

Key features: Pre-delivery and post-delivery email protection, Secure Email Gateway (SEG) and API-based deployment options, Business Email Compromise (BEC) and impersonation detection, Multi-layered threat detection for known and unknown threats, SPF and DMARC email authentication support

View Bitdefender GravityZone Extended Email Security|Bitdefender GravityZone Extended Email Security alternatives|Compare Bitdefender GravityZone Extended Email Security

All 48 Alternatives & Competitors to Cisco Secure Email Threat Defense

Compare

Microsoft Defender for Office 365

Email and collaboration security for Microsoft 365 environments

Email Security Platforms

Compare

Abnormal Security Cloud-based email security platform

AI-powered email security platform protecting against phishing, BEC, and ATO

Email Security Platforms

Compare

Vade (Hornetsecurity) 365 Total Protection

AI-powered email security platform for Microsoft 365 with backup & compliance.

Email Security Platforms

Compare

Fortinet FortiMail Email Security

AI-powered email security platform protecting against phishing, BEC, and ATO

Email Security Platforms

Compare

Cellopoint Cloud Email Security Solution

Cloud-based email security platform protecting against phishing, ransomware, BEC

Email Security Platforms

Compare

Mimecast Advanced Email Security

Email security platform protecting M365 & Google Workspace from threats

Email Security Platforms

Compare

ESET Cloud Office Security

Cloud email security for Microsoft 365 and Google Workspace applications

Email Security Platforms

Compare

Bitdefender GravityZone Extended Email Security

Cloud-native email security platform with SEG and API-based protection

Email Security Platforms

Compare

OPSWAT MetaDefender Email Security

Email security platform protecting against phishing, malware, and exploits

Email Security Platforms

Compare

VIPRE Integrated Email Security (IES)

Email security platform for Microsoft 365 with AI-based threat detection

Email Security Platforms

Compare

Egress Intelligent Email Security

Cloud email security platform for inbound/outbound threat detection & DLP

Email Security Platforms

Compare

Mimecast Collaboration Threat Protection

Secures Microsoft Teams, SharePoint & OneDrive from malware and phishing

Email Security Platforms

Compare

API-based email security platform for Microsoft 365 environments

Email Security Platforms

Compare

KnowBe4 Cloud Email Security

AI-driven email security platform for Microsoft 365 inbound/outbound threats

Email Security Platforms

Compare

ConnectWise Email Security

Email security platform with AI threat detection, BEC protection, and DLP

Email Security Platforms

Compare

GLIMPS Email Security for M365

AI-based email security for M365 with phishing, BEC & malware detection.

Email Security Platforms

Compare

Hornetsecurity 365 Total Protection

Comprehensive M365 security suite with email protection, backup, and compliance

Email Security Platforms

Compare

odix FileWallTM for Microsoft 365

File-based threat protection for Microsoft 365 using CDR technology

Email Security Platforms

Compare

Broadcom Symantec Email Security

Enterprise email security platform for cloud and on-premise deployments

Email Security Platforms

Compare

Darktrace Email Security

AI-powered email security platform detecting threats across email and messaging

Email Security Platforms

Compare

TitanHQ Cybersecurity Bundles

Bundled cybersecurity solutions for MSPs and end users with email protection

Email Security Platforms

Compare

InSAT Security Inbox

Centralized platform for reporting, analyzing, and responding to email threats

Email Security Platforms

Compare

Vircom Email Security

Email security platform enhanced with multi-tenant mgmt & automation tools

Email Security Platforms

Compare

SourcetekIT Email Security Service

Managed email security service for Office 365 using Cisco's platform.

Email Security Platforms

Compare

SpamTitan for Office 365

Email security layer for M365 with anti-phishing, sandboxing, and DLP.

Email Security Platforms

Compare

Unified AI-powered cybersecurity & cyber insurance platform for SMBs.

Email Security Platforms

Compare

AI-Powered Email Security & DMARC Protection

AI-powered DMARC monitoring and email authentication security platform

Email Security Platforms

Compare

Cloudflare Cloud Email Security

Cloudflare Cloud Email Security is a cloud-based email protection service that safeguards organizations against phishing, malware, spam, and other email-borne threats through integrated threat detection and prevention capabilities.

Email Security Platforms

Compare

INKY Behavioral Email Security Platform

Behavioral email security platform protecting inbound, outbound, and internal mail

Email Security Platforms

Compare

Email security platform with phishing/BEC protection and MDR/XDR integration

Email Security Platforms

Compare

Hornetsecurity Advanced Threat Protection

AI-powered email security platform protecting against advanced threats

Email Security Platforms

Compare

TrustLayer Mail

Email security platform with inline threat protection and compliant archiving

Email Security Platforms

Compare

SorbSecurity Cloud Email Security

Cloud-based email security platform protecting against phishing & ransomware

Email Security Platforms

Compare

GreatHorn Email Security

Cloud-native email security platform for phishing detection and response

Email Security Platforms

Compare

Trustifi AI Powered Email Security

AI-powered email security platform for threat detection and compliance

Email Security Platforms

Compare

MX Layer Email Security

Cloud-based email security platform with AI-powered threat detection

Email Security Platforms

Compare

Trend Micro Trend Vision One™

AI-powered email and collaboration security platform for threat detection

Email Security Platforms

Compare

Proofpoint Threat Protection

Email security platform with AI-based threat detection and DLP capabilities

Email Security Platforms

Compare

AnubisNetworks Email Security

Email security platform protecting against fraud, malware, and spam threats

Email Security Platforms

Compare

ESET Mail Security

Email security for Microsoft Exchange servers with anti-spam and anti-malware

Email Security Platforms

Compare

Material Security Email Security

Cloud workspace security platform for email, files, and account protection

Email Security Platforms

Compare

Bitdefender GravityZone Security for Exchange

Email security for Microsoft Exchange servers with antispam and antimalware.

Email Security Platforms

Compare

Comodo Secure Email Gateway

Cloud-based email gateway with spam filtering, anti-phishing, and containment

Email Security Platforms

Compare

MX Layer Email Compliance

Email compliance and archiving solution with DLP and threat protection

Email Security Platforms

Compare

VIPRE Email Archiving

Cloud-based email archiving solution for compliance and e-discovery

Email Security Platforms

Compare

Cybersentriq MX Email Threat Protection

MX-based email security platform using AI to block spam, phishing & malware

Email Security Platforms

Compare

ThreatDown Email Security

AI-powered email security platform for phishing and BEC protection

Email Security Platforms

Compare

IRONSCALES Adaptive AI Email Security

AI-powered email security platform with behavioral detection and automation

Email Security Platforms

Also compare alternatives to:

Microsoft Defender for Office 365 alternatives Abnormal Security Cloud-based email security platform alternatives Vade (Hornetsecurity) 365 Total Protection alternatives Fortinet FortiMail Email Security alternatives Cellopoint Cloud Email Security Solution alternatives Mimecast Advanced Email Security alternatives ESET Cloud Office Security alternatives Bitdefender GravityZone Extended Email Security alternatives OPSWAT MetaDefender Email Security alternatives VIPRE Integrated Email Security (IES) alternatives Egress Intelligent Email Security alternatives Mimecast Collaboration Threat Protection alternatives

Compare Cisco Secure Email Threat Defense with:

Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365 Cisco Secure Email Threat Defense vs Abnormal Security Cloud-based email security platform Cisco Secure Email Threat Defense vs Vade (Hornetsecurity) 365 Total Protection Cisco Secure Email Threat Defense vs Fortinet FortiMail Email Security Cisco Secure Email Threat Defense vs Cellopoint Cloud Email Security Solution Cisco Secure Email Threat Defense vs Mimecast Advanced Email Security Cisco Secure Email Threat Defense vs ESET Cloud Office Security Cisco Secure Email Threat Defense vs Bitdefender GravityZone Extended Email Security

Cisco Secure Email Threat Defense Alternatives FAQ

Common questions security professionals ask when evaluating alternatives and competitors to Cisco Secure Email Threat Defense.

What are the best alternatives to Cisco Secure Email Threat Defense?

The most popular alternatives to Cisco Secure Email Threat Defense include Microsoft Defender for Office 365, Abnormal Security Cloud-based email security platform, Vade (Hornetsecurity) 365 Total Protection, Fortinet FortiMail Email Security, and Cellopoint Cloud Email Security Solution. These Email Security Platforms tools offer similar capabilities and are frequently compared by security professionals evaluating their options.

How many alternatives to Cisco Secure Email Threat Defense are available?

There are 48 alternatives to Cisco Secure Email Threat Defense listed on CybersecTools, all within the Email Security Platforms category. Each alternative is matched based on shared capabilities, tags, and NIST CSF coverage areas.

Is Cisco Secure Email Threat Defense free or commercial?

Cisco Secure Email Threat Defense is a commercial Email Security Platforms tool. It requires a paid license or subscription. Both free and commercial alternatives are available for comparison.

What type of tool is Cisco Secure Email Threat Defense?

Cisco Secure Email Threat Defense is a Email Security Platforms tool within the broader Email Security category. It is used by security professionals for email security platforms capabilities and can be compared against 48 similar tools.

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