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Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365
Compare features, pricing, and capabilities to find the right tool for your security needs.

Cisco Secure Email Threat Defense
Email threat protection for Microsoft 365 with advanced detection capabilities

Microsoft Defender for Office 365
Email and collaboration security for Microsoft 365 environments
Side-by-Side Comparison
- Advanced threat detection for known, emerging, and targeted threats
- Malicious technique identification with business risk context
- Real-time threat search and remediation
- Searchable threat telemetry and categorization
- Vulnerability assessment by organizational unit
- Microsoft 365 integration
- AI-powered sentiment analysis for email filtering
- Inline protection against malicious links and attachments in Outlook and Teams
- Real-time detonation of attachments and links
- Automated BEC attack disruption with user disabling and device isolation
- Post-delivery removal of malicious emails
- Extended detection and response (XDR) capabilities
- Security posture optimization with recommended configurations
- Priority account support for sensitive accounts
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Compare Other ToolsCisco Secure Email Threat Defense vs Microsoft Defender for Office 365: Complete 2026 Comparison
Choosing between Cisco Secure Email Threat Defense and Microsoft Defender for Office 365 for your email security platforms needs? This comprehensive comparison analyzes both tools across key dimensions including features, pricing, integrations, and user reviews to help you make an informed decision. Both solutions are popular choices in the email security platforms space, each with unique strengths and capabilities.
Cisco Secure Email Threat Defense: Email threat protection for Microsoft 365 with advanced detection capabilities
Microsoft Defender for Office 365: Email and collaboration security for Microsoft 365 environments
Frequently Asked Questions
What is the difference between Cisco Secure Email Threat Defense and Microsoft Defender for Office 365?
Cisco Secure Email Threat Defense and Microsoft Defender for Office 365 are both Email Security Platforms solutions. Cisco Secure Email Threat Defense Email threat protection for Microsoft 365 with advanced detection capabilities. Microsoft Defender for Office 365 Email and collaboration security for Microsoft 365 environments. The main differences lie in their feature sets, pricing models, and integration capabilities.
Which is better: Cisco Secure Email Threat Defense or Microsoft Defender for Office 365?
The choice between Cisco Secure Email Threat Defense and Microsoft Defender for Office 365 depends on your specific requirements. Cisco Secure Email Threat Defense is a commercial solution, while Microsoft Defender for Office 365 is a commercial solution. Consider factors like your budget, team size, required integrations, and specific security needs when making your decision.
Is Cisco Secure Email Threat Defense a good alternative to Microsoft Defender for Office 365?
Yes, Cisco Secure Email Threat Defense can be considered as an alternative to Microsoft Defender for Office 365 for Email Security Platforms needs. Both tools offer Email Security Platforms capabilities, though they may differ in specific features, pricing, and ease of use. Compare their feature sets above to determine which better fits your organization's requirements.
What are the pricing differences between Cisco Secure Email Threat Defense and Microsoft Defender for Office 365?
Cisco Secure Email Threat Defense is Commercial and Microsoft Defender for Office 365 is Commercial. Cisco Secure Email Threat Defense requires a paid subscription. Microsoft Defender for Office 365 requires a paid subscription. Contact each vendor for detailed pricing information.
Can Cisco Secure Email Threat Defense and Microsoft Defender for Office 365 be used together?
Depending on your security architecture, Cisco Secure Email Threat Defense and Microsoft Defender for Office 365 might complement each other as part of a defense-in-depth strategy. However, as both are Email Security Platforms tools, most organizations choose one primary solution. Evaluate your specific needs and consider consulting with security professionals for the best approach.
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