Secretarium Confidential Computing is a platform that processes data within Trusted Execution Environments (TEEs) to protect information from unauthorized access during computation. The platform isolates applications in secure enclaves that are cryptographically measured and provide remote attestation capabilities to verify the integrity of the computation environment. The solution uses hardware-based confidential computing to create isolated secure regions within memory, separate from the operating system and other system components. This approach differs from virtualization-based methods by establishing a smaller trust boundary that excludes hypervisors and OS stacks. The platform implements memory encryption and offers a verifier-agnostic remote attestation workflow, allowing organizations to validate attestation quotes independently or through third-party verifiers. This design supports sensitive data collaboration across multiple parties. Secretarium is designed to support regulatory compliance requirements including AML, GDPR, and HIPAA. The platform includes the Klave component, which is optimized to minimize performance overhead through enhanced data locality, refined memory management, and efficient TEE architecture. The solution handles various workload types with different performance characteristics: computation-intensive tasks experience minimal impact, linear memory operations maintain low overhead, while memory-intensive or random access operations may see slight overhead when data exceeds CPU L3 cache size.