Vaultree Data-In-Use Encryption is a data protection solution that maintains encryption during storage, transmission, and active use of data. The technology combines Next-Gen Fully Homomorphic Encryption (FHE), Searchable Encryption (SE), One-Way Functions (OWF), and Multi-Key Encryption to enable operations on encrypted data without requiring decryption. The solution is delivered through the Vaultree Encrypted Data Suite (VEDS), which provides modular encryption capabilities via APIs and SDKs. These modules support encrypted search, sharing, storage, and analysis operations. The platform includes cryptographic access control with single-use keys, digital cryptographic signing for each interaction, and multi-key encryption for federated analytics across different parties. The technology supports computations such as statistical aggregations, encrypted search queries, and machine learning training or inference directly on ciphertext. Data does not need to be centralized on third-party repositories or platforms, as the modular components integrate within existing product stacks and enterprise data pipelines. The solution provides cryptographic audit trails and ensures keys are not exposed to storage providers or administrators. Organizations can implement Zero-Trust architecture through cryptographic access control and one-way encrypted search functions. The platform is designed for minimal performance impact compared to plaintext operations and supports compliance requirements for regulations including GDPR and HIPAA.