NexiFuse Health is a decentralized infrastructure platform designed for healthcare data management and interoperability. The system operates as a sovereign data layer that integrates with existing electronic medical record (EMR) systems including Epic and Cerner without replacing them. The platform uses blockchain technology with zero-knowledge proofs to verify access permissions while maintaining data encryption. Patient records are encrypted at rest using AES encryption, and access control is managed through on-chain verification where patients hold private keys to grant or revoke provider access. The architecture includes three main components: NexiFuse Hub software that serves as a gateway integrating with EMR systems and managing local encryption keys, NexiFuse Edge hardware nodes for on-premise data processing and AI inference, and NexiFuse Vault for encrypted data storage with cryptographic isolation between records. The system maintains HIPAA compliance and creates audit trails of all data access and consent actions. Data exchange occurs through encrypted channels where decryption keys are released only after zero-knowledge proofs verify the request. The platform supports decentralized identity (DID) management for patients and providers. Local node execution ensures data sovereignty by processing sensitive information within institutional infrastructure, with only verifiable proofs and access grants broadcast to the network.