Proofpoint Threat Protection vs Microsoft Defender for Office 365
Compare features, pricing, and capabilities to find the right tool for your security needs.
Proofpoint Threat Protection
Email security platform with AI-based threat detection and DLP capabilities
Microsoft Defender for Office 365
Email and collaboration security for Microsoft 365 environments
Side-by-Side Comparison
- AI-based email threat detection and prevention
- Phishing and business email compromise protection
- Adaptive email DLP with machine learning
- Email encryption with policy-based controls
- Account takeover protection
- CASB for cloud application security
- Email fraud defense and DMARC compliance
- Insider threat management
- AI-powered sentiment analysis for email filtering
- Inline protection against malicious links and attachments in Outlook and Teams
- Real-time detonation of attachments and links
- Automated BEC attack disruption with user disabling and device isolation
- Post-delivery removal of malicious emails
- Extended detection and response (XDR) capabilities
- Security posture optimization with recommended configurations
- Priority account support for sensitive accounts
Need help choosing?
Explore more tools in this category or create a security stack with your selections.
Want to compare different tools?
Compare Other ToolsProofpoint Threat Protection vs Microsoft Defender for Office 365: Complete 2026 Comparison
Choosing between Proofpoint Threat Protection and Microsoft Defender for Office 365 for your email security platforms needs? This comprehensive comparison analyzes both tools across key dimensions including features, pricing, integrations, and user reviews to help you make an informed decision. Both solutions are popular choices in the email security platforms space, each with unique strengths and capabilities.
Proofpoint Threat Protection: Email security platform with AI-based threat detection and DLP capabilities
Microsoft Defender for Office 365: Email and collaboration security for Microsoft 365 environments
Frequently Asked Questions
What is the difference between Proofpoint Threat Protection and Microsoft Defender for Office 365?
Proofpoint Threat Protection and Microsoft Defender for Office 365 are both Email Security Platforms solutions. Proofpoint Threat Protection Email security platform with AI-based threat detection and DLP capabilities. Microsoft Defender for Office 365 Email and collaboration security for Microsoft 365 environments. The main differences lie in their feature sets, pricing models, and integration capabilities.
Which is better: Proofpoint Threat Protection or Microsoft Defender for Office 365?
The choice between Proofpoint Threat Protection and Microsoft Defender for Office 365 depends on your specific requirements. Proofpoint Threat Protection is a commercial solution, while Microsoft Defender for Office 365 is a commercial solution. Consider factors like your budget, team size, required integrations, and specific security needs when making your decision.
Is Proofpoint Threat Protection a good alternative to Microsoft Defender for Office 365?
Yes, Proofpoint Threat Protection can be considered as an alternative to Microsoft Defender for Office 365 for Email Security Platforms needs. Both tools offer Email Security Platforms capabilities, though they may differ in specific features, pricing, and ease of use. Compare their feature sets above to determine which better fits your organization's requirements.
What are the pricing differences between Proofpoint Threat Protection and Microsoft Defender for Office 365?
Proofpoint Threat Protection is Commercial and Microsoft Defender for Office 365 is Commercial. Proofpoint Threat Protection requires a paid subscription. Microsoft Defender for Office 365 requires a paid subscription. Contact each vendor for detailed pricing information.
Can Proofpoint Threat Protection and Microsoft Defender for Office 365 be used together?
Depending on your security architecture, Proofpoint Threat Protection and Microsoft Defender for Office 365 might complement each other as part of a defense-in-depth strategy. However, as both are Email Security Platforms tools, most organizations choose one primary solution. Evaluate your specific needs and consider consulting with security professionals for the best approach.
Related Comparisons
Explore More Email Security Platforms Tools
Discover and compare all email security platforms solutions in our comprehensive directory.
Looking for a different comparison? Explore our complete tool comparison directory.
Compare Other Tools