AI Gateway vs F5 AI Guardrails: Side-by-Side Comparison (2026)

AI Gateway: Centralized gateway for accessing and securing AI models with routing & monitoring. built by NeuralTrust. Core capabilities include Centralized access to multiple AI models through single endpoint, Smart traffic routing based on cost, latency, or policy, Failover and automatic recovery mechanisms..

F5 AI Guardrails: Runtime security for AI models, agents, and data with guardrails and compliance. built by F5. Core capabilities include Protection against prompt injection and jailbreak attacks, Runtime data leakage detection and prevention, Automated compliance auditing for GDPR, HIPAA, and EUAIA..

Both serve the LLM Guardrails market but differ in approach, feature depth, and target audience.

AI Gateway differentiates with Centralized access to multiple AI models through single endpoint, Smart traffic routing based on cost, latency, or policy, Failover and automatic recovery mechanisms. F5 AI Guardrails differentiates with Protection against prompt injection and jailbreak attacks, Runtime data leakage detection and prevention, Automated compliance auditing for GDPR, HIPAA, and EUAIA.

AI Gateway is developed by NeuralTrust. F5 AI Guardrails is developed by F5. Vendor maturity, funding stage, and team size can be important factors when evaluating long-term viability and support quality.

AI Gateway and F5 AI Guardrails serve similar LLM Guardrails use cases: both are LLM Guardrails tools. Review the feature comparison above to determine which fits your requirements.