Cortex XDR is Palo Alto Networks' extended detection and response platform that provides endpoint security with AI-driven threat prevention, detection, and response capabilities. The platform achieved 99% in both threat prevention and response in the 2025 AV Comparatives EPR Test and demonstrated 100% detection with no delays or configuration changes in MITRE ATT&CK Evaluations Round 6. Cortex XDR operates on a single data lake architecture that serves as the foundation for Cortex XSIAM, Palo Alto Networks' unified AI-driven SOC platform. The platform combines industry-leading prevention capabilities with unmatched detection accuracy to reduce risk and save analyst time. It integrates with Unit 42 managed services including 24/7 Managed Detection and Response (MDR), Managed Threat Hunting, Incident Response, and Cyber Risk Management services. Unit 42 MDR operates natively inside the Cortex XDR tenant to proactively hunt, monitor, and remediate threats. Cortex XDR has been recognized as a Leader in the 2025 Gartner Magic Quadrant for Endpoint Protection Platforms and The Forrester Wave for Extended Detection and Response Platforms Q2 2024. The platform received AAA rating with 100% prevention in the July 2025 SE Labs Ransomware Test and holds certifications from AV-Comparatives for Anti-Tampering and EDR Detection Validation. It provides comprehensive endpoint defense powered by AI and threat intelligence to detect and respond to multi-domain attacks across the enterprise environment.