Microsoft Defender vs ThreatLocker Application Allowlisting: side-by-side comparison (2026)

Microsoft Defender: Security app for individuals/families protecting devices from online threats. Built by Microsoft.

ThreatLocker Application Allowlisting: Application allowlisting that blocks unauthorized software by default. Built by ThreatLocker.

The table above shows where their features, integrations, deployment and company size fit differ.

Microsoft Defender is made by Microsoft. ThreatLocker Application Allowlisting is made by ThreatLocker. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.

Often, yes. Microsoft Defender and ThreatLocker Application Allowlisting are both Endpoint Protection Platform products. Use the table above to see where features, deployment and company size fit differ.