Agilicus vs Zscaler Secure Private Access with ZTNA: Side-by-Side Comparison (2026)

Short answer

Teams protecting OT and ICS environments without the luxury of deploying agents will find Agilicus solves a real problem: clientless zero trust access to PLCs, HMIs, and SCADA systems that can't run traditional security software. The no-inbound-ports architecture means your critical infrastructure never exposes attack surface to the internet, and support for federated identity providers lets you enforce MFA across resources that typically have none. Skip this if your primary concern is securing standard IT applications and desktops; plenty of lighter-weight ZTNA platforms handle that use case better and cheaper. Mid-market and enterprise security teams replacing VPN with zero trust will find Zscaler Secure Private Access with ZTNA most valuable for its application segmentation that actually works without network discovery hell; the AI-powered policy automation cuts weeks of manual access mapping. The workload-to-workload segmentation across hybrid and multicloud environments maps directly to NIST PR.AA identity controls, and the inline Layer 7 inspection prevents the access-granted-now-exploited-later scenario that plagues simpler ZTNA deployments. Skip this if you need the strictest on-premises-only architecture or lack the hybrid infrastructure to justify the complexity; pure network microsegmentation tools will do less and cost less.

Based on our analysis of core features, integrations, company size fit, deployment model, here is our conclusion: