Agilicus is a commercial zero trust network access tool by Agilicus. ThreatLocker Zero Trust Solution is a commercial zero trust network access tool by threatlocker. Compare features, ratings, integrations, and community reviews side by side to find the best zero trust network access fit for your security stack.
Based on our analysis of NIST CSF 2.0 coverage, core features, integrations, company size fit, here is our conclusion:
Teams protecting OT and ICS environments without the luxury of deploying agents will find Agilicus solves a real problem: clientless zero trust access to PLCs, HMIs, and SCADA systems that can't run traditional security software. The no-inbound-ports architecture means your critical infrastructure never exposes attack surface to the internet, and support for federated identity providers lets you enforce MFA across resources that typically have none. Skip this if your primary concern is securing standard IT applications and desktops; plenty of lighter-weight ZTNA platforms handle that use case better and cheaper.
ThreatLocker Zero Trust Solution
Mid-market and enterprise teams with Windows-heavy environments should choose ThreatLocker Zero Trust Solution if application control is your security foundation, not a secondary layer. Its allowlisting engine with automatic learning algorithms eliminates the overhead of manual policy tuning that kills most zero trust deployments in practice, and the deny-by-default posture directly addresses NIST PR.AA access control requirements. Skip this if your organization runs heavily on macOS or Linux, or if you need detection-first capabilities; ThreatLocker assumes you're willing to break things temporarily to prevent them from being weaponized.
Clientless ZTNA platform for secure access to apps, OT, and ICS resources.
Zero Trust endpoint protection platform with allowlisting and network control
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Common questions about comparing Agilicus vs ThreatLocker Zero Trust Solution for your zero trust network access needs.
Agilicus: Clientless ZTNA platform for secure access to apps, OT, and ICS resources. built by Agilicus. headquartered in Canada. Core capabilities include Clientless, agentless secure access to applications, desktops, shares, and OT resources, Multi-factor authentication (MFA) enforcement across all resource types, Single sign-on (SSO) via federated identity providers..
ThreatLocker Zero Trust Solution: Zero Trust endpoint protection platform with allowlisting and network control. built by threatlocker. headquartered in United States. Core capabilities include Application allowlisting with automatic learning algorithms, Ringfencing to control application interactions and prevent weaponization, Network Control with just-in-time port management..
Both serve the Zero Trust Network Access market but differ in approach, feature depth, and target audience.
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