PyIOCe is an OpenIOC editor built using Python 2.7 and wxPython 3.0.0.0 that enables security professionals to create, edit, and manage Indicators of Compromise (IOCs). The tool supports both OpenIOC 1.0 and 1.1 formats simultaneously, with OpenIOC 1.0 support limited to MIR (Mandiant Intelligent Response) using legacy MIR terms. It provides a keyboard-driven interface for efficient IOC manipulation and editing. Key functionality includes indicator term management, parameter management, and IOC cloning capabilities. Users can configure preferences for default IOC version, context, and author settings. The editor supports standard operations like cut, copy, paste, and drag-and-drop functionality for the indicator tree structure. The tool allows users to revert IOC changes to the last saved state and provides comprehensive indicator terms and parameters definition capabilities. It integrates with other security systems including Snort, GRR, Splunk, and Yara for broader threat intelligence operations. PyIOCe is designed to operationalize threat intelligence data into reduced search methods, enabling both broad threat behavior analysis and narrow threat identification during incident response activities across enterprise networks.