Infoblox Threat Defense is a DNS-layer security solution that uses predictive threat intelligence to block threats before they reach users, devices, or cloud workloads. The platform monitors over 204,000 threat actor clusters and blocks domain-based threats an average of 68.4 days before they are confirmed as malicious by traditional tools. The solution operates at the DNS layer to provide protective DNS capabilities, blocking attacker infrastructure before it is weaponized. It maintains a false positive rate of 0.0002% across more than 20 million indicators. The platform blocks 82% of domain-based threats before the first DNS query occurs. Infoblox Threat Defense includes a Security Workspace that provides real-time visibility and guidance for security teams. The platform integrates with existing security tools through the Infoblox Security Ecosystem to enable automated threat detection and response. Additional capabilities include SOC Insights for AI-driven analytics that reduce alert fatigue, Lookalike Domain Monitoring to identify brand impersonation threats, and Domain Mitigation Services that work with global regulators and registrars to take down malicious domains. The solution is designed to protect infrastructure across cloud, core, edge, remote users, and IoT environments. It aims to reduce SOC analyst workload by approximately 6,000 hours per year.