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Trellix Wise is a commercial extended detection and response tool by Trellix. Cisco XDR is a commercial extended detection and response tool by Cisco. Compare features, ratings, integrations, and community reviews side by side to find the best extended detection and response fit for your security stack.
CST VerdictBased on our analysis of NIST CSF 2.0 coverage, core features, integrations, company size fit, here is our conclusion:
Mid-market and enterprise SOCs drowning in alert volume will see immediate relief from Trellix Wise's GenAI-powered investigation automation, which cuts the manual triage work that burns out analysts. The platform trains on 1.5 petabytes of security data and ingests real-time threat intelligence from 68 billion daily queries, giving it pattern recognition that generic LLMs cannot match. This tool excels at the DE.AE and RS.AN layers of NIST CSF 2.0,detection and investigation,but offers less on the recovery side, so teams needing deep automation of containment and remediation workflows should evaluate whether Trellix XDR's native capabilities fill that gap before committing.
Mid-market and enterprise security teams with fragmented detection across network, endpoint, and email will see the fastest ROI from Cisco XDR, since its multi-domain correlation actually connects alerts that your existing point tools miss. The platform covers DE.CM and DE.AE strongly, meaning detection is genuinely its strength; RS.MI (containment and recovery) is present but less mature than what you get from pure endpoint-focused vendors. Skip this if your team is still optimizing a single-vendor stack like Palo Alto or CrowdStrike; XDR's real value emerges only when you're already drowning in disconnected alerts.
GenAI-powered security operations platform for automated alert investigation
XDR platform with AI-driven threat detection across network, endpoint, email, cloud
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Common questions about comparing Trellix Wise vs Cisco XDR for your extended detection and response needs.
Trellix Wise: GenAI-powered security operations platform for automated alert investigation. built by Trellix. headquartered in United States. Core capabilities include Automated alert investigation, GenAI-powered conversational interface for threat hunting, Automated escalation with contextual information..
Cisco XDR: XDR platform with AI-driven threat detection across network, endpoint, email, cloud. built by Cisco. headquartered in United States. Core capabilities include AI-driven incident prioritization and threat detection, Network-based threat detection and visibility, Automated containment and response actions..
Both serve the Extended Detection and Response market but differ in approach, feature depth, and target audience.
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