Palo Alto Networks Prisma AIRS vs Zscaler SPLX Platform: Side-by-Side Comparison (2026)

Palo Alto Networks Prisma AIRS

Enterprise security teams securing internal AI development and third-party agent deployments need Prisma AIRS because it catches prompt injection and data exfiltration risks that standard application security misses entirely. The platform covers the full AI lifecycle from model scanning through runtime protection, and its MCP threat detection addresses the emerging agent architecture risks most competitors ignore. Skip this if your organization hasn't yet deployed custom AI agents or large language models in production; Prisma AIRS solves a problem you don't have yet, and the pricing reflects enterprise scope.

Zscaler SPLX Platform

Mid-market and enterprise security teams deploying internal LLM applications need Zscaler SPLX Platform because it's the only platform that treats AI systems as supply chain risk, not just another application to monitor. The platform covers the full NIST lifecycle from ID.AM asset discovery through DE.CM runtime inspection, with native jailbreak detection and automated red teaming that catches prompt injection attacks before they reach production. Skip this if your organization hasn't yet built or integrated custom LLM applications; you're paying for capabilities you won't use for another 18 months.