Netskope One Threat Protection vs Zscaler Internet Access: Side-by-Side Comparison (2026)

Netskope One Threat Protection

Mid-market and enterprise teams replacing legacy web gateways will see immediate ROI from Netskope One Threat Protection's inline malware detection; the multistage sandboxing across 30+ file types with heuristic deobfuscation catches polymorph and obfuscated attacks that signature-only tools miss. The retrohunt API and patient zero protection mean you're not just blocking today's threats but hunting backwards through your traffic for files you've already seen, mapping NIST DE.CM and DE.AE functions that most SSE platforms treat as afterthoughts. Skip this if your threat lab has time to manually analyze suspicious files or if you need equally strong recovery and response capabilities; Netskope prioritizes detection and forensics over incident response orchestration.

Zscaler Internet Access

Mid-market and enterprise security teams replacing on-premise web gateways will find Zscaler Internet Access worth the migration effort because it actually inspects encrypted traffic at scale without killing performance, something most cloud SSE platforms struggle with. The platform covers DE.CM and DE.AE through continuous monitoring and AI-powered threat detection across DNS, URLs, and files, giving you visibility into what your old gateway missed. Skip this if your organization needs deep integration with on-prem infrastructure or runs custom legacy applications that depend on transparent proxy architecture; Zscaler's cloud-first design optimizes for modern SaaS and internet access, not hybrid networks.