Our take
What our shortlists say about each one.
- Cisco Secure Email Threat Defense
Best for: Cisco shops wanting Talos-backed filtering
It is on the list as a Microsoft 365 product that can grow with you: you start in API mode and add the inline gateway later, from the same console. That suits a team that already runs Cisco security. Check fit first if you run Google Workspace or your own mail servers, because the product is built for Microsoft 365.
From Best Email Security Solutions for Business, Fall 2026
- Palo Alto Networks Unit 42 Managed XSIAM
Best for: Large companies standardizing on Cortex XSIAM
Unit 42 Managed XSIAM is on the list for scope, because one service covers endpoints, cloud, network, identity and email with threat hunting and custom detection engineering. It fits mid-market and enterprise companies that are standardizing on Cortex XSIAM, since the service runs on that platform. Weigh that commitment before you sign, because leaving the service also means leaving the platform.
From Best MDR Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
