Palo Alto Networks Cortex XDR vs Trend Micro Vision One: Side-by-Side Comparison (2026)

Palo Alto Networks Cortex XDR: AI-driven XDR platform for endpoint security with threat prevention and detection. built by Palo Alto Networks. Core capabilities include AI-driven threat prevention and detection with 99% prevention rate in AV Comparatives EPR Test, 100% detection accuracy in MITRE ATT&CK Evaluations Round 6 with no delays or configuration changes, Single data lake architecture for unified security operations and analytics..

Trend Micro Vision One: XDR platform for endpoints, servers, and cloud workloads with EDR capabilities. built by Trend Micro. Core capabilities include Extended detection and response across endpoints, servers, and cloud workloads, Endpoint detection and response capabilities, Virtual patching for unpatched vulnerabilities..

Both serve the Extended Detection and Response market but differ in approach, feature depth, and target audience.

Palo Alto Networks Cortex XDR differentiates with AI-driven threat prevention and detection with 99% prevention rate in AV Comparatives EPR Test, 100% detection accuracy in MITRE ATT&CK Evaluations Round 6 with no delays or configuration changes, Single data lake architecture for unified security operations and analytics. Trend Micro Vision One differentiates with Extended detection and response across endpoints, servers, and cloud workloads, Endpoint detection and response capabilities, Virtual patching for unpatched vulnerabilities.

Palo Alto Networks Cortex XDR is developed by Palo Alto Networks. Trend Micro Vision One is developed by Trend Micro. Vendor maturity, funding stage, and team size can be important factors when evaluating long-term viability and support quality.

Palo Alto Networks Cortex XDR and Trend Micro Vision One serve similar Extended Detection and Response use cases: both are Extended Detection and Response tools. Review the feature comparison above to determine which fits your requirements.