Cisco Secure Email Threat Defense is a commercial email security platforms solution by Cisco. Hoplite Artemis Web and Mail is a commercial email security platforms solution by Hoplite Industries. Features, integrations, deployment and the company behind each one, side by side.
What our shortlists say about the one we picked.
Best for: Cisco shops wanting Talos-backed filtering
It is on the list as a Microsoft 365 product that can grow with you: you start in API mode and add the inline gateway later, from the same console. That suits a team that already runs Cisco security. Check fit first if you run Google Workspace or your own mail servers, because the product is built for Microsoft 365.
From Best Email Security Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
Email threat protection for Microsoft 365 with advanced detection capabilities
Email and web threat detection platform with AI-based behavioral analysis
See more solutions in this category, or build a security stack from your picks.
Based on what each listing shows: deployment, company size, price and open source.
Cisco Secure Email Threat Defense fits if you want a cloud product.
Hoplite Artemis Web and Mail fits if you need both cloud and on-premises options.
Common questions when comparing Cisco Secure Email Threat Defense vs Hoplite Artemis Web and Mail for email security platforms.
Cisco Secure Email Threat Defense: Email threat protection for Microsoft 365 with advanced detection capabilities. Built by Cisco.
Hoplite Artemis Web and Mail: Email and web threat detection platform with AI-based behavioral analysis. Built by Hoplite Industries.
The table above shows where their features, integrations, deployment and company size fit differ.
Cisco Secure Email Threat Defense is made by Cisco. Hoplite Artemis Web and Mail is made by Hoplite Industries. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.
Often, yes. Cisco Secure Email Threat Defense and Hoplite Artemis Web and Mail are both Email Security Platforms products. Use the table above to see where features, deployment and company size fit differ.
Need the answer fast? Best Email Security Solutions for Business picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more.See the shortlist
