ESET Cloud Office Security is a commercial email security platforms solution by ESET. Microsoft Defender for Office 365 is a commercial email security platforms solution by Microsoft. Features, integrations, deployment and the company behind each one, side by side.
What our shortlists say about the one we picked.
Best for: Teams running Microsoft 365
It is on the list because it is built into Microsoft 365, and many companies already own it through their license, so the buying question is often settled before you start. That makes it the natural first layer if you run Microsoft 365. Decide whether it covers your risk alone or needs a second product beside it, since it is built to work with other email security products.
From Best Email Security Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
Cloud email security for Microsoft 365 and Google Workspace applications
Email and collaboration security for Microsoft 365 environments
See more solutions in this category, or build a security stack from your picks.
Common questions when comparing ESET Cloud Office Security vs Microsoft Defender for Office 365 for email security platforms.
ESET Cloud Office Security: Cloud email security for Microsoft 365 and Google Workspace applications. Built by ESET.
Microsoft Defender for Office 365: Email and collaboration security for Microsoft 365 environments. Built by Microsoft.
The table above shows where their features, integrations, deployment and company size fit differ.
ESET Cloud Office Security is made by ESET. Microsoft Defender for Office 365 is made by Microsoft. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.
Often, yes. ESET Cloud Office Security and Microsoft Defender for Office 365 are both Email Security Platforms products, and both cover Microsoft 365. Use the table above to see where features, deployment and company size fit differ.
Need the answer fast? Best Email Security Solutions for Business picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more.See the shortlist