Defguard Zero-Trust VPN Server with MFA vs ZeroTier One: side-by-side comparison (2026)
Defguard Zero-Trust VPN Server with MFA is a commercial VPN solution by Defguard. ZeroTier One is a commercial VPN solution by ZeroTier. Features, integrations, deployment and the company behind each one, side by side.
Open-source WireGuard VPN server with MFA and zero-trust access control
Software-defined overlay networking platform with encrypted P2P connectivity.
Side-by-side comparison
Feature
Defguard Zero-Trust VPN Server with MFA
ZeroTier One
Pricing model
Commercial
Commercial
Category
VPN
VPN
Deployment and fit
Deployment type
Hybrid
Hybrid
Company size fit
SMB, Mid-Market, Enterprise
Startup, SMB, Mid-Market, Enterprise
Company
Company
Defguard
ZeroTier
Use cases and capabilities
WireGuard
Yes
No
Open Source
Yes
No
Private Networks
No
Yes
Encryption
No
Yes
Network Segmentation
No
Yes
ZTNA
No
Yes
Zero Trust Architecture
No
Yes
Remote Access
No
Yes
Network Administration
No
Yes
Microsegmentation
No
Yes
IoT Security
No
Yes
SD-WAN
No
Yes
Core features
10 features listed
10 features listed
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