Agilicus vs Defguard Zero-Trust VPN Server with MFA: Side-by-Side Comparison (2026)

Agilicus: Clientless ZTNA platform for secure access to apps, OT, and ICS resources. built by Agilicus. Core capabilities include Clientless, agentless secure access to applications, desktops, shares, and OT resources, Multi-factor authentication (MFA) enforcement across all resource types, Single sign-on (SSO) via federated identity providers..

Defguard Zero-Trust VPN Server with MFA: Open-source WireGuard VPN server with MFA and zero-trust access control. built by Defguard. Core capabilities include Multi-factor authentication integrated with WireGuard protocol, Management of multiple isolated VPN instances, Session-based randomly generated WireGuard pre-shared keys..

Both serve the Zero Trust Network Access market but differ in approach, feature depth, and target audience.

Agilicus differentiates with Clientless, agentless secure access to applications, desktops, shares, and OT resources, Multi-factor authentication (MFA) enforcement across all resource types, Single sign-on (SSO) via federated identity providers. Defguard Zero-Trust VPN Server with MFA differentiates with Multi-factor authentication integrated with WireGuard protocol, Management of multiple isolated VPN instances, Session-based randomly generated WireGuard pre-shared keys.

Agilicus is developed by Agilicus. Defguard Zero-Trust VPN Server with MFA is developed by Defguard. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.

Agilicus and Defguard Zero-Trust VPN Server with MFA serve similar Zero Trust Network Access use cases. Review the feature comparison above to determine which fits your requirements.