OPSWAT MetaDefender Drive 2 vs Uptycs Nexus: Side-by-Side Comparison (2026)

OPSWAT MetaDefender Drive 2: Pre-boot USB device for scanning laptops/desktops with multi-engine malware detection. built by OPSWAT. Core capabilities include Pre-boot scanning from USB without software installation, Multiscanning with up to 7 anti-malware engines, File-based vulnerability assessment for 20,000+ applications..

Uptycs Nexus: Managed SaaS for osquery fleet management across endpoints. built by Uptycs. Core capabilities include Centralized osquery fleet management and telemetry collection, Real-time and scheduled query execution across endpoints, Query pack creation and automated execution..

Both serve the Endpoint Protection Platform market but differ in approach, feature depth, and target audience.

OPSWAT MetaDefender Drive 2 differentiates with Pre-boot scanning from USB without software installation, Multiscanning with up to 7 anti-malware engines, File-based vulnerability assessment for 20,000+ applications. Uptycs Nexus differentiates with Centralized osquery fleet management and telemetry collection, Real-time and scheduled query execution across endpoints, Query pack creation and automated execution.

OPSWAT MetaDefender Drive 2 is developed by OPSWAT. Uptycs Nexus is developed by Uptycs. Vendor maturity, funding stage, and team size can be important factors when evaluating long-term viability and support quality.

OPSWAT MetaDefender Drive 2 integrates with Avira, BitDefender, ESET, K7 Security, Trellix and 5 more. Uptycs Nexus integrates with AWS SSM, SCCM, JAMF, Chef, Puppet and 1 more. Check integration compatibility with your existing security stack before deciding.

OPSWAT MetaDefender Drive 2 and Uptycs Nexus serve similar Endpoint Protection Platform use cases: both are Endpoint Protection Platform tools. Review the feature comparison above to determine which fits your requirements.