Microsoft Defender for Endpoint is a commercial endpoint detection and response solution by Microsoft. Sophos EDR is a commercial endpoint detection and response solution by Sophos. Features, integrations, deployment and the company behind each one, side by side.
What our shortlists say about each one.
Best for: Teams already running Microsoft 365
It earns a place because it covers phones as well as desktops and servers, and many companies already own it through their Microsoft 365 license, so the first question is what you have paid for already. Its alerts flow into Microsoft's other security products, which suits a Microsoft-centric estate of any size. If you run a mixed stack, test how well its alerts reach the SIEM and SOAR you already use.
From Best Endpoint Security Solutions for Business, Fall 2026
Best for: Teams already running Sophos Endpoint
It belongs here for teams that already run Sophos Endpoint, because EDR turns on from the same console without a new agent. It fits teams of any size that want AI help ranking and summing up detections. You can also run it with Microsoft Defender as the protection agent, which helps if you are moving between the two.
From Best EDR Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
Multiplatform endpoint security with detection and response capabilities
Endpoint detection and response that finds and stops human-led attacks.
See more solutions in this category, or build a security stack from your picks.
Based on what each listing shows: deployment, company size, price and open source.
Microsoft Defender for Endpoint fits if you want a cloud product.
Sophos EDR fits if you need both cloud and on-premises options.
Common questions when comparing Microsoft Defender for Endpoint vs Sophos EDR for endpoint detection and response.
Microsoft Defender for Endpoint: Multiplatform endpoint security with detection and response capabilities, built by Microsoft.
Sophos EDR: Endpoint detection and response that finds and stops human-led attacks, built by Sophos.
The table above shows where their features, integrations, deployment and company size fit differ.
Microsoft Defender for Endpoint is made by Microsoft. Sophos EDR is made by Sophos. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.
Often, yes. Microsoft Defender for Endpoint and Sophos EDR are both Endpoint Detection and Response products, and both cover Ransomware Prevention. Use the table above to see where features, deployment and company size fit differ.
Need the answer fast? Best EDR Solutions for Business picks CrowdStrike Agentic Endpoint Security, Microsoft Defender for Endpoint, SentinelOne Singularity Endpoint and 4 more.See the shortlist