Microsoft Defender for Endpoint is a commercial endpoint detection and response solution by Microsoft. SentinelOne Singularity Endpoint is a commercial endpoint detection and response solution by SentinelOne. Features, integrations, deployment and the company behind each one, side by side.
What our shortlists say about each one.
Best for: Teams already running Microsoft 365
It earns a place because it covers phones as well as desktops and servers, and many companies already own it through their Microsoft 365 license, so the first question is what you have paid for already. Its alerts flow into Microsoft's other security products, which suits a Microsoft-centric estate of any size. If you run a mixed stack, test how well its alerts reach the SIEM and SOAR you already use.
From Best Endpoint Security Solutions for Business, Fall 2026
Best for: Teams wanting automatic response and rollback
Its place comes from response it can run on its own, with AI on the device that works offline and rollback in one click. It suits teams of any size that are short on analysts and want the agent to act first. It also covers identity attacks and mobile devices, so decide whether you want those in scope now or later.
From Best EDR Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
Multiplatform endpoint security with detection and response capabilities
AI-powered endpoint protection platform with EDR and identity security
See more solutions in this category, or build a security stack from your picks.
Common questions when comparing Microsoft Defender for Endpoint vs SentinelOne Singularity Endpoint for endpoint detection and response.
Microsoft Defender for Endpoint: Multiplatform endpoint security with detection and response capabilities, built by Microsoft.
SentinelOne Singularity Endpoint: AI-powered endpoint protection platform with EDR and identity security, built by SentinelOne.
The table above shows where their features, integrations, deployment and company size fit differ.
Microsoft Defender for Endpoint is made by Microsoft. SentinelOne Singularity Endpoint is made by SentinelOne. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.
Often, yes. Microsoft Defender for Endpoint and SentinelOne Singularity Endpoint are both Endpoint Detection and Response products, and both cover Ransomware Prevention. Use the table above to see where features, deployment and company size fit differ.
Need the answer fast? Best EDR Solutions for Business picks CrowdStrike Agentic Endpoint Security, Microsoft Defender for Endpoint, SentinelOne Singularity Endpoint and 4 more.See the shortlist