Cisco Duo Remote Access is a commercial zero trust network access solution by Duo Security. Threatmatic Zero Trust Edge is a commercial zero trust network access solution by Threatmatic. Features, integrations, deployment and the company behind each one, side by side.
What our shortlists say about the one we picked.
Best for: Teams needing phishing-resistant MFA layered on VPN or ZTNA
The integration with Cisco XDR for VPN capacity scaling is relevant only if you are already in the Cisco ecosystem. The database lists no specific third-party integrations, which is a gap to verify during evaluation. Duo fits SMB through enterprise teams that want strong MFA and device trust as the foundation of their access security, whether or not they have completed a full VPN-to-ZTNA migration. It is also a natural fit for organizations that have already deployed Duo for MFA and want to extend it into a broader access control posture.
From Best ZTNA Solutions for Business, Fall 2026
Reviewed by Nika (Nikoloz) Kokhreidze.
Remote access security solution with phishing-resistant MFA and device trust
ZTNA platform with microsegmentation, VPN replacement, and GenAI analytics.
See more solutions in this category, or build a security stack from your picks.
Based on what each listing shows: deployment, company size, price and open source.
Cisco Duo Remote Access fits if you want a cloud product.
Threatmatic Zero Trust Edge fits if you need both cloud and on-premises options.
Common questions when comparing Cisco Duo Remote Access vs Threatmatic Zero Trust Edge for zero trust network access.
Cisco Duo Remote Access: Remote access security solution with phishing-resistant MFA and device trust, built by Duo Security.
Threatmatic Zero Trust Edge: ZTNA platform with microsegmentation, VPN replacement, and GenAI analytics, built by Threatmatic.
The table above shows where their features, integrations, deployment and company size fit differ.
Cisco Duo Remote Access is made by Duo Security. Threatmatic Zero Trust Edge is made by Threatmatic. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.
Often, yes. Cisco Duo Remote Access and Threatmatic Zero Trust Edge are both Zero Trust Network Access products, and both cover ZTNA, Hybrid Work. Use the table above to see where features, deployment and company size fit differ.
Need the answer fast? Best ZTNA Solutions for Business picks Zscaler Private Access (ZPA), Netskope One Private Access, Palo Alto Networks Prisma Access ZTNA 2.0 and 4 more.See the shortlist