# Cisco Secure Email Threat Defense Cisco Secure Email Threat Defense is an Email Security Platforms product by Cisco. It runs in the cloud. Pricing is commercial (contact sales). Email threat protection for Microsoft 365 with advanced detection capabilities Checked October 2026. ## What is Cisco Secure Email Threat Defense? Cisco Secure Email Threat Defense is an email security solution designed specifically for Microsoft 365 environments. The product provides protection against email-based threats including known, emerging, and targeted attacks. The solution offers advanced threat detection capabilities to identify malicious techniques and provides context for business-specific risks. It includes searchable threat telemetry that categorizes threats and identifies which parts of an organization are most vulnerable to attack. The product enables security teams to rapidly search for dangerous threats and remediate all threat instances in real time. It expands defensive scope beyond basic email filtering to detect sophisticated attack methods. Cisco Secure Email Threat Defense is offered as a cloud-based service that integrates with Microsoft 365 email infrastructure. The solution is available through a 30-day free trial, after which it operates on a commercial licensing model based on user seat count. The product provides visibility into email threats through threat telemetry and categorization features, allowing organizations to understand their email security posture and respond to incidents more effectively. Tags: Microsoft 365, Threat Analysis ## Where it fits in your security program (NIST CSF 2.0) - [Detect](https://cybersectools.com/guides/building-detect-program-small-team): helps you spot attacks and unusual activity. - [Respond](https://cybersectools.com/guides/building-respond-program-small-team): helps you contain and handle incidents. ## Quick facts - Category: [Email & Messaging Security](https://cybersectools.com/categories/email-security) ยท [Email Security Platforms](https://cybersectools.com/categories/email-security-platforms) - Vendor: [Cisco](https://cybersectools.com/companies/cisco) - Deployment: Cloud - Company size fit: SMB, Mid-Market, Enterprise - Pricing model: Commercial (contact sales) - Features: 9 listed - Integrations: 3 listed - Website: cisco.com The full feature and integration lists are on the page for signed-in visitors. ## Where it ranks Cisco Secure Email Threat Defense is #5 of 7 on [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms). ## Awards - Category Leader, Q3 2026: [Email Security Platforms](https://cybersectools.com/categories/email-security-platforms) - Category Leader, Q2 2026: [Email Security Platforms](https://cybersectools.com/categories/email-security-platforms) How badges are earned: [/badges](https://cybersectools.com/badges) ## Who is Cisco Secure Email Threat Defense best for? Cisco shops wanting Talos-backed filtering. It is on the list as a Microsoft 365 product that can grow with you: you start in API mode and add the inline gateway later, from the same console. That suits a team that already runs Cisco security. Check fit first if you run Google Workspace or your own mail servers, because the product is built for Microsoft 365. Our take, from #5 of 7 on [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). ## Cisco Secure Email Threat Defense FAQ ### What is Cisco Secure Email Threat Defense? Cisco Secure Email Threat Defense is a product by Cisco in the Email Security Platforms category. It covers Microsoft 365 and Threat Analysis. ### What is the pricing for Cisco Secure Email Threat Defense? Cisco Secure Email Threat Defense is a commercial product. For pricing, visit https://www.cisco.com/site/us/en/products/security/secure-email/index.html or contact Cisco. ### What are alternatives to Cisco Secure Email Threat Defense? Alternatives to Cisco Secure Email Threat Defense listed on CybersecTools: 1. [Fortra Email Security & Anti-Phishing](https://cybersectools.com/tools/fortra-email-security-and-anti-phishing) - Email security platform protecting against phishing, BEC, and data loss (Commercial) 2. [Ocean Agentic Email Security Platform](https://cybersectools.com/tools/ocean-agentic-email-security-platform) - Agentic AI email security platform that investigates emails pre-delivery. (Commercial) 3. [Microsoft Defender for Office 365](https://cybersectools.com/tools/microsoft-defender-for-office-365) - Email and collaboration security for Microsoft 365 environments (Commercial) 4. [NoSpamProxy Protection](https://cybersectools.com/tools/nospamproxy-protection) - Email gateway that blocks spam, phishing and malware before inbox delivery, made (Commercial) 5. [Fortinet FortiMail Email and Workspace Security](https://cybersectools.com/tools/fortinet-fortimail-email-security) - AI-powered email security platform protecting against phishing, BEC, and ATO (Commercial) Compare all Cisco Secure Email Threat Defense alternatives at [https://cybersectools.com/alternatives/cisco-secure-email-threat-defense](https://cybersectools.com/alternatives/cisco-secure-email-threat-defense) ### What deployment and organization size does Cisco Secure Email Threat Defense fit? Cisco Secure Email Threat Defense is available as a cloud service. It is listed for small businesses, mid-market companies and enterprises. Pricing is commercial. Ask Cisco for pricing and support terms. ## Compare Cisco Secure Email Threat Defense with similar solutions - [Cisco Secure Email Threat Defense vs Fortra Email Security & Anti-Phishing](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-fortra-email-security-and-anti-phishing) - [Cisco Secure Email Threat Defense vs Ocean Agentic Email Security Platform](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-ocean-agentic-email-security-platform) - [Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-microsoft-defender-for-office-365) All alternatives to Cisco Secure Email Threat Defense: [/alternatives/cisco-secure-email-threat-defense](https://cybersectools.com/alternatives/cisco-secure-email-threat-defense) --- Source: https://cybersectools.com/tools/cisco-secure-email-threat-defense For AI agents: every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md, and any compare page has a Markdown copy too (add .md to its URL). More on Cisco Secure Email Threat Defense and Cisco: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=product-md