# Palo Alto Networks Prisma Access ZTNA 2.0 vs ThreatLocker Zero Trust Network Access: side-by-side comparison (2026) [Palo Alto Networks Prisma Access ZTNA 2.0](https://cybersectools.com/tools/palo-alto-networks-prisma-access-ztna) is a commercial [zero trust network access](https://cybersectools.com/categories/ztna) solution by [Palo Alto Networks](https://cybersectools.com/companies/palo-alto-networks). [ThreatLocker Zero Trust Network Access](https://cybersectools.com/tools/threatlocker-zero-trust-network-access) is a commercial [zero trust network access](https://cybersectools.com/categories/ztna) solution by [ThreatLocker](https://cybersectools.com/companies/threatlocker). Features, integrations, deployment and the company behind each one, side by side. ## Our take What our shortlists say about the one we picked. ### [Palo Alto Networks Prisma Access ZTNA 2.0](https://cybersectools.com/tools/palo-alto-networks-prisma-access-ztna) Best for: Prisma Access customers wanting app-level private access It earns its place for control inside the session, because App-ID can allow an app but block an upload, and one DLP policy can cover private and SaaS apps. Support for overlapping subnets helps after a merger. It comes as part of Prisma Access for mid-market and enterprise, so weigh it as a platform decision rather than a stand-alone ZTNA buy. From [Best ZTNA Solutions for Business](https://cybersectools.com/shortlists/best-ztna-solutions), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). Need the answer fast? [Best ZTNA Solutions for Business](https://cybersectools.com/shortlists/best-ztna-solutions) picks Zscaler Private Access (ZPA), Netskope One Private Access, Palo Alto Networks Prisma Access ZTNA 2.0 and 4 more. ## Side-by-side comparison | | Palo Alto Networks Prisma Access ZTNA 2.0 | ThreatLocker Zero Trust Network Access | |---|---|---| | Pricing model | Commercial | Commercial | | Category | Zero Trust Network Access | Zero Trust Network Access | | Verified | No | No | | Deployment type | Cloud | Cloud | | Company size fit | Mid-Market, Enterprise | SMB, Mid-Market, Enterprise | | Company | Palo Alto Networks | ThreatLocker | | Headquarters | – | – | ### Use cases and capabilities | | Palo Alto Networks Prisma Access ZTNA 2.0 | ThreatLocker Zero Trust Network Access | |---|---|---| | Least Privilege | Yes | Yes | | Remote Access | Yes | Yes | | SASE | Yes | – | | ZTNA | Yes | Yes | | Zero Trust Architecture | – | Yes | | Lateral Movement | – | Yes | | Authorization | – | Yes | | Network Protection | – | Yes | | Hybrid Work | – | Yes | | RDP | – | Yes | | Policy | – | Yes | ### Core features **Palo Alto Networks Prisma Access ZTNA 2.0** 10 features listed. Sign in on the page to see them. **ThreatLocker Zero Trust Network Access** 7 features listed. Sign in on the page to see them. ### Integrations **Palo Alto Networks Prisma Access ZTNA 2.0** 14 integrations listed. Sign in on the page to see them. **ThreatLocker Zero Trust Network Access** No integrations listed. ## Which one fits you Based on what each listing shows: deployment, company size, price and open source. - [ThreatLocker Zero Trust Network Access](https://cybersectools.com/tools/threatlocker-zero-trust-network-access) fits if you are a small business. ## Palo Alto Networks Prisma Access ZTNA 2.0 vs ThreatLocker Zero Trust Network Access FAQ Common questions when comparing Palo Alto Networks Prisma Access ZTNA 2.0 vs ThreatLocker Zero Trust Network Access for zero trust network access. ### What is the difference between Palo Alto Networks Prisma Access ZTNA 2.0 and ThreatLocker Zero Trust Network Access? **Palo Alto Networks Prisma Access ZTNA 2.0**: Cloud-delivered ZTNA 2.0 for private apps with app-level least-privilege access, built by Palo Alto Networks. **ThreatLocker Zero Trust Network Access**: ZTNA that brokers access from authorized users/devices to internal resources, no VPN, built by ThreatLocker. The table above shows where their features, integrations, deployment and company size fit differ. ### Who makes Palo Alto Networks Prisma Access ZTNA 2.0 and ThreatLocker Zero Trust Network Access? **Palo Alto Networks Prisma Access ZTNA 2.0** is made by Palo Alto Networks. **ThreatLocker Zero Trust Network Access** is made by ThreatLocker. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit. ### Is Palo Alto Networks Prisma Access ZTNA 2.0 a good alternative to ThreatLocker Zero Trust Network Access? Often, yes. Palo Alto Networks Prisma Access ZTNA 2.0 and ThreatLocker Zero Trust Network Access are both Zero Trust Network Access products, and both cover ZTNA, Remote Access, Least Privilege. Use the table above to see where features, deployment and company size fit differ. ## Related comparisons - [Palo Alto Networks Prisma Access ZTNA 2.0 vs Threatmatic Zero Trust Edge](https://cybersectools.com/compare/palo-alto-networks-prisma-access-ztna-vs-threatmatic-zero-trust-edge) - [Palo Alto Networks Prisma Access ZTNA 2.0 vs QuantLayer Secure Remote Access](https://cybersectools.com/compare/palo-alto-networks-prisma-access-ztna-vs-quantlayer-secure-remote-access) - [Palo Alto Networks Prisma Access ZTNA 2.0 vs Alkira Zero Trust Network Access](https://cybersectools.com/compare/alkira-ztna-vs-palo-alto-networks-prisma-access-ztna) - [ThreatLocker Zero Trust Network Access vs Threatmatic Zero Trust Edge](https://cybersectools.com/compare/threatlocker-zero-trust-network-access-vs-threatmatic-zero-trust-edge) - [ThreatLocker Zero Trust Network Access vs QuantLayer Secure Remote Access](https://cybersectools.com/compare/quantlayer-secure-remote-access-vs-threatlocker-zero-trust-network-access) - [ThreatLocker Zero Trust Network Access vs Alkira Zero Trust Network Access](https://cybersectools.com/compare/alkira-ztna-vs-threatlocker-zero-trust-network-access) ## Alternatives to each - [See all Palo Alto Networks Prisma Access ZTNA 2.0 alternatives](https://cybersectools.com/alternatives/palo-alto-networks-prisma-access-ztna) - [See all ThreatLocker Zero Trust Network Access alternatives](https://cybersectools.com/alternatives/threatlocker-zero-trust-network-access) --- Source: https://cybersectools.com/compare/palo-alto-networks-prisma-access-ztna-vs-threatlocker-zero-trust-network-access For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/palo-alto-networks-prisma-access-ztna.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md. More on Palo Alto Networks Prisma Access ZTNA 2.0 and ThreatLocker Zero Trust Network Access: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md