# Palo Alto Networks Enterprise Data Loss Prevention vs SpinOne Microsoft 365 DLP: side-by-side comparison (2026) [Palo Alto Networks Enterprise Data Loss Prevention](https://cybersectools.com/tools/palo-alto-networks-enterprise-data-loss-prevention) is a commercial [data loss prevention](https://cybersectools.com/categories/dlp) solution by [Palo Alto Networks](https://cybersectools.com/companies/palo-alto-networks). [SpinOne Microsoft 365 DLP](https://cybersectools.com/tools/spinone-microsoft-365-dlp) is a commercial [data loss prevention](https://cybersectools.com/categories/dlp) solution by [Spin.AI](https://cybersectools.com/companies/spinai). Features, integrations, deployment and the company behind each one, side by side. ## Our take What our shortlists say about the one we picked. ### [Palo Alto Networks Enterprise Data Loss Prevention](https://cybersectools.com/tools/palo-alto-networks-enterprise-data-loss-prevention) Best for: Teams running Palo Alto firewalls or Prisma Access It earns its place because one policy follows data across network, SaaS, endpoint and AI apps, so you do not write the same rule in several consoles. It enforces through Prisma Access, Prisma Browser and Palo Alto firewalls, which makes it the natural pick if you already run them. If you do not, weigh the platform you would need to adopt to get it. From [Best Data Protection Solutions for Business](https://cybersectools.com/shortlists/best-data-protection-solutions), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). ## Side-by-side comparison | | Palo Alto Networks Enterprise Data Loss Prevention | SpinOne Microsoft 365 DLP | |---|---|---| | Pricing model | Commercial | Commercial | | Category | Data Loss Prevention | Data Loss Prevention | | Verified | No | No | | Deployment type | Hybrid | Cloud | | Company size fit | SMB, Mid-Market, Enterprise | SMB, Mid-Market, Enterprise | | Company | Palo Alto Networks | Spin.AI | | Headquarters | – | – | ### Use cases and capabilities | | Palo Alto Networks Enterprise Data Loss Prevention | SpinOne Microsoft 365 DLP | |---|---|---| | SASE | Yes | – | | Microsoft 365 | – | Yes | | PII | – | Yes | | Alerting | – | Yes | ### Core features **Palo Alto Networks Enterprise Data Loss Prevention** 10 features listed. Sign in on the page to see them. **SpinOne Microsoft 365 DLP** 8 features listed. Sign in on the page to see them. ### Integrations **Palo Alto Networks Enterprise Data Loss Prevention** 24 integrations listed. Sign in on the page to see them. **SpinOne Microsoft 365 DLP** 48 integrations listed. Sign in on the page to see them. ## Which one fits you Based on what each listing shows: deployment, company size, price and open source. - [Palo Alto Networks Enterprise Data Loss Prevention](https://cybersectools.com/tools/palo-alto-networks-enterprise-data-loss-prevention) fits if you need both cloud and on-premises options. - [SpinOne Microsoft 365 DLP](https://cybersectools.com/tools/spinone-microsoft-365-dlp) fits if you want a cloud product. ## Palo Alto Networks Enterprise Data Loss Prevention vs SpinOne Microsoft 365 DLP FAQ Common questions when comparing Palo Alto Networks Enterprise Data Loss Prevention vs SpinOne Microsoft 365 DLP for data loss prevention. ### What is the difference between Palo Alto Networks Enterprise Data Loss Prevention and SpinOne Microsoft 365 DLP? **Palo Alto Networks Enterprise Data Loss Prevention**: Enterprise DLP solution protecting sensitive data across networks, clouds, and endpoints. Built by Palo Alto Networks. **SpinOne Microsoft 365 DLP**: DLP solution for Microsoft 365 with automated data leak prevention capabilities. Built by Spin.AI. The table above shows where their features, integrations, deployment and company size fit differ. ### Who makes Palo Alto Networks Enterprise Data Loss Prevention and SpinOne Microsoft 365 DLP? **Palo Alto Networks Enterprise Data Loss Prevention** is made by Palo Alto Networks. **SpinOne Microsoft 365 DLP** is made by Spin.AI. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit. ### Is Palo Alto Networks Enterprise Data Loss Prevention a good alternative to SpinOne Microsoft 365 DLP? Often, yes. Palo Alto Networks Enterprise Data Loss Prevention and SpinOne Microsoft 365 DLP are both Data Loss Prevention products. Use the table above to see where features, deployment and company size fit differ. ## Related comparisons - [Palo Alto Networks Enterprise Data Loss Prevention vs Microsoft Purview Data Loss Prevention](https://cybersectools.com/compare/microsoft-purview-data-loss-prevention-vs-palo-alto-networks-enterprise-data-loss-prevention) - [Palo Alto Networks Enterprise Data Loss Prevention vs Safetica Intelligent Data Security](https://cybersectools.com/compare/palo-alto-networks-enterprise-data-loss-prevention-vs-safetica-intelligent-data-security) - [Palo Alto Networks Enterprise Data Loss Prevention vs Strac Data Security](https://cybersectools.com/compare/palo-alto-networks-enterprise-data-loss-prevention-vs-strac-data-security) - [SpinOne Microsoft 365 DLP vs Microsoft Purview Data Loss Prevention](https://cybersectools.com/compare/microsoft-purview-data-loss-prevention-vs-spinone-microsoft-365-dlp) - [SpinOne Microsoft 365 DLP vs Safetica Intelligent Data Security](https://cybersectools.com/compare/safetica-intelligent-data-security-vs-spinone-microsoft-365-dlp) - [SpinOne Microsoft 365 DLP vs Strac Data Security](https://cybersectools.com/compare/spinone-microsoft-365-dlp-vs-strac-data-security) ## Alternatives to each - [See all Palo Alto Networks Enterprise Data Loss Prevention alternatives](https://cybersectools.com/alternatives/palo-alto-networks-enterprise-data-loss-prevention) - [See all SpinOne Microsoft 365 DLP alternatives](https://cybersectools.com/alternatives/spinone-microsoft-365-dlp) --- Source: https://cybersectools.com/compare/palo-alto-networks-enterprise-data-loss-prevention-vs-spinone-microsoft-365-dlp For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/palo-alto-networks-enterprise-data-loss-prevention.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md. More on Palo Alto Networks Enterprise Data Loss Prevention and SpinOne Microsoft 365 DLP: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md