# Nucleon EDR vs Uptycs Nexus: side-by-side comparison (2026)

[Nucleon EDR](https://cybersectools.com/tools/nucleon-nucleon-edr) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [Nucleon Security](https://cybersectools.com/companies/nucleon-security). [Uptycs Nexus](https://cybersectools.com/tools/uptycs-nexus) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [Uptycs](https://cybersectools.com/companies/uptycs). Features, integrations, deployment and the company behind each one, side by side.

Need the answer fast? [Best EDR Solutions for Business](https://cybersectools.com/shortlists/best-edr-solutions) picks CrowdStrike Agentic Endpoint Security, Microsoft Defender for Endpoint, SentinelOne Singularity Endpoint and 4 more.

## Side-by-side comparison

| | Nucleon EDR | Uptycs Nexus |
|---|---|---|
| Pricing model | Commercial | Commercial |
| Category | Endpoint Detection and Response | Endpoint Detection and Response |
| Verified | No | No |
| Deployment type | Cloud | Cloud |
| Company size fit | SMB, Mid-Market, Enterprise | Startup, SMB, Mid-Market, Enterprise |
| Company | Nucleon Security | Uptycs |
| Headquarters | – | – |

### Use cases and capabilities

| | Nucleon EDR | Uptycs Nexus |
|---|---|---|
| osquery | – | Yes |

### Core features

**Nucleon EDR**

10 features listed. Sign in on the page to see them.

**Uptycs Nexus**

10 features listed. Sign in on the page to see them.

### Integrations

**Nucleon EDR**

1 integration listed. Sign in on the page to see them.

**Uptycs Nexus**

6 integrations listed. Sign in on the page to see them.

## Which one fits you

Based on what each listing shows: deployment, company size, price and open source.

- [Uptycs Nexus](https://cybersectools.com/tools/uptycs-nexus) fits if you are a startup.

## Nucleon EDR vs Uptycs Nexus FAQ

Common questions when comparing Nucleon EDR vs Uptycs Nexus for endpoint detection and response.

### What is the difference between Nucleon EDR and Uptycs Nexus?

**Nucleon EDR**: EDR solution with Zero Trust architecture and AI-based malware detection, built by Nucleon Security.

**Uptycs Nexus**: Managed SaaS for osquery fleet management across endpoints, built by Uptycs.

The table above shows where their features, integrations, deployment and company size fit differ.

### Who makes Nucleon EDR and Uptycs Nexus?

**Nucleon EDR** is made by Nucleon Security. **Uptycs Nexus** is made by Uptycs. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.

### Is Nucleon EDR a good alternative to Uptycs Nexus?

Often, yes. Nucleon EDR and Uptycs Nexus are both Endpoint Detection and Response products. Use the table above to see where features, deployment and company size fit differ.

## Related comparisons

- [Nucleon EDR vs Huawei HiSec Endpoint](https://cybersectools.com/compare/huawei-hisec-endpoint-vs-nucleon-nucleon-edr)
- [Nucleon EDR vs Microsoft Defender for Endpoint](https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-nucleon-nucleon-edr)
- [Nucleon EDR vs Sophos EDR](https://cybersectools.com/compare/nucleon-nucleon-edr-vs-sophos-intercept-x)
- [Uptycs Nexus vs Huawei HiSec Endpoint](https://cybersectools.com/compare/huawei-hisec-endpoint-vs-uptycs-nexus)
- [Uptycs Nexus vs Microsoft Defender for Endpoint](https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-uptycs-nexus)
- [Uptycs Nexus vs Sophos EDR](https://cybersectools.com/compare/sophos-intercept-x-vs-uptycs-nexus)

## Alternatives to each

- [See all Nucleon EDR alternatives](https://cybersectools.com/alternatives/nucleon-nucleon-edr)
- [See all Uptycs Nexus alternatives](https://cybersectools.com/alternatives/uptycs-nexus)

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Source: https://cybersectools.com/compare/nucleon-nucleon-edr-vs-uptycs-nexus

For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/nucleon-nucleon-edr.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md.

More on Nucleon EDR and Uptycs Nexus: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md