# Microsoft Defender for Endpoint vs Uptycs Nexus: side-by-side comparison (2026) [Microsoft Defender for Endpoint](https://cybersectools.com/tools/microsoft-defender-for-endpoint) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [Microsoft](https://cybersectools.com/companies/microsoft). [Uptycs Nexus](https://cybersectools.com/tools/uptycs-nexus) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [Uptycs](https://cybersectools.com/companies/uptycs). Features, integrations, deployment and the company behind each one, side by side. ## Our take What our shortlists say about the one we picked. ### [Microsoft Defender for Endpoint](https://cybersectools.com/tools/microsoft-defender-for-endpoint) Best for: Teams already running Microsoft 365 It earns a place because it covers phones as well as desktops and servers, and many companies already own it through their Microsoft 365 license, so the first question is what you have paid for already. Its alerts flow into Microsoft's other security products, which suits a Microsoft-centric estate of any size. If you run a mixed stack, test how well its alerts reach the SIEM and SOAR you already use. From [Best Endpoint Security Solutions for Business](https://cybersectools.com/shortlists/best-endpoint-security-solutions), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). Need the answer fast? [Best EDR Solutions for Business](https://cybersectools.com/shortlists/best-edr-solutions) picks CrowdStrike Agentic Endpoint Security, Microsoft Defender for Endpoint, SentinelOne Singularity Endpoint and 4 more. ## Side-by-side comparison | | Microsoft Defender for Endpoint | Uptycs Nexus | |---|---|---| | Pricing model | Commercial | Commercial | | Category | Endpoint Detection and Response | Endpoint Detection and Response | | Verified | No | No | | Deployment type | Cloud | Cloud | | Company size fit | SMB, Mid-Market, Enterprise | Startup, SMB, Mid-Market, Enterprise | | Company | Microsoft | Uptycs | | Headquarters | – | – | ### Use cases and capabilities | | Microsoft Defender for Endpoint | Uptycs Nexus | |---|---|---| | Ransomware Prevention | Yes | – | | osquery | – | Yes | ### Core features **Microsoft Defender for Endpoint** 10 features listed. Sign in on the page to see them. **Uptycs Nexus** 10 features listed. Sign in on the page to see them. ### Integrations **Microsoft Defender for Endpoint** 29 integrations listed. Sign in on the page to see them. **Uptycs Nexus** 6 integrations listed. Sign in on the page to see them. ## Which one fits you Based on what each listing shows: deployment, company size, price and open source. - [Uptycs Nexus](https://cybersectools.com/tools/uptycs-nexus) fits if you are a startup. ## Microsoft Defender for Endpoint vs Uptycs Nexus FAQ Common questions when comparing Microsoft Defender for Endpoint vs Uptycs Nexus for endpoint detection and response. ### What is the difference between Microsoft Defender for Endpoint and Uptycs Nexus? **Microsoft Defender for Endpoint**: Multiplatform endpoint security with detection and response capabilities, built by Microsoft. **Uptycs Nexus**: Managed SaaS for osquery fleet management across endpoints, built by Uptycs. The table above shows where their features, integrations, deployment and company size fit differ. ### Who makes Microsoft Defender for Endpoint and Uptycs Nexus? **Microsoft Defender for Endpoint** is made by Microsoft. **Uptycs Nexus** is made by Uptycs. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit. ### Is Microsoft Defender for Endpoint a good alternative to Uptycs Nexus? Often, yes. Microsoft Defender for Endpoint and Uptycs Nexus are both Endpoint Detection and Response products. Use the table above to see where features, deployment and company size fit differ. ## Related comparisons - [Microsoft Defender for Endpoint vs Huawei HiSec Endpoint](https://cybersectools.com/compare/huawei-hisec-endpoint-vs-microsoft-defender-for-endpoint) - [Microsoft Defender for Endpoint vs Sophos EDR](https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-sophos-intercept-x) - [Microsoft Defender for Endpoint vs Bitdefender GravityZone EDR](https://cybersectools.com/compare/bitdefender-gravityzone-edr-cloud-vs-microsoft-defender-for-endpoint) - [Uptycs Nexus vs Huawei HiSec Endpoint](https://cybersectools.com/compare/huawei-hisec-endpoint-vs-uptycs-nexus) - [Uptycs Nexus vs Sophos EDR](https://cybersectools.com/compare/sophos-intercept-x-vs-uptycs-nexus) - [Uptycs Nexus vs Bitdefender GravityZone EDR](https://cybersectools.com/compare/bitdefender-gravityzone-edr-cloud-vs-uptycs-nexus) ## Alternatives to each - [See all Microsoft Defender for Endpoint alternatives](https://cybersectools.com/alternatives/microsoft-defender-for-endpoint) - [See all Uptycs Nexus alternatives](https://cybersectools.com/alternatives/uptycs-nexus) --- Source: https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-uptycs-nexus For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/microsoft-defender-for-endpoint.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md. More on Microsoft Defender for Endpoint and Uptycs Nexus: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md