# Microsoft Defender for Endpoint vs ThreatDown Endpoint Detection & Response: side-by-side comparison (2026) [Microsoft Defender for Endpoint](https://cybersectools.com/tools/microsoft-defender-for-endpoint) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [Microsoft](https://cybersectools.com/companies/microsoft). [ThreatDown Endpoint Detection & Response](https://cybersectools.com/tools/threatdown-endpoint-detection-and-response) is a commercial [endpoint detection and response](https://cybersectools.com/categories/edr) solution by [ThreatDown by Malwarebytes](https://cybersectools.com/companies/threatdown-by-malwarebytes). Features, integrations, deployment and the company behind each one, side by side. ## Our take What our shortlists say about the one we picked. ### [Microsoft Defender for Endpoint](https://cybersectools.com/tools/microsoft-defender-for-endpoint) Best for: Teams already running Microsoft 365 It earns a place because it covers phones as well as desktops and servers, and many companies already own it through their Microsoft 365 license, so the first question is what you have paid for already. Its alerts flow into Microsoft's other security products, which suits a Microsoft-centric estate of any size. If you run a mixed stack, test how well its alerts reach the SIEM and SOAR you already use. From [Best Endpoint Security Solutions for Business](https://cybersectools.com/shortlists/best-endpoint-security-solutions), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). Need the answer fast? [Best EDR Solutions for Business](https://cybersectools.com/shortlists/best-edr-solutions) picks CrowdStrike Agentic Endpoint Security, Microsoft Defender for Endpoint, SentinelOne Singularity Endpoint and 4 more. ## Side-by-side comparison | | Microsoft Defender for Endpoint | ThreatDown Endpoint Detection & Response | |---|---|---| | Pricing model | Commercial | Commercial | | Category | Endpoint Detection and Response | Endpoint Detection and Response | | Verified | No | No | | Deployment type | Cloud | Cloud | | Company size fit | SMB, Mid-Market, Enterprise | SMB, Mid-Market, Enterprise | | Company | Microsoft | ThreatDown by Malwarebytes | | Headquarters | – | – | ### Use cases and capabilities | | Microsoft Defender for Endpoint | ThreatDown Endpoint Detection & Response | |---|---|---| | Ransomware Prevention | Yes | Yes | | Attack Detection | – | Yes | ### Core features **Microsoft Defender for Endpoint** 10 features listed. Sign in on the page to see them. **ThreatDown Endpoint Detection & Response** 7 features listed. Sign in on the page to see them. ### Integrations **Microsoft Defender for Endpoint** 29 integrations listed. Sign in on the page to see them. **ThreatDown Endpoint Detection & Response** 16 integrations listed. Sign in on the page to see them. ## Microsoft Defender for Endpoint vs ThreatDown Endpoint Detection & Response FAQ Common questions when comparing Microsoft Defender for Endpoint vs ThreatDown Endpoint Detection & Response for endpoint detection and response. ### What is the difference between Microsoft Defender for Endpoint and ThreatDown Endpoint Detection & Response? **Microsoft Defender for Endpoint**: Multiplatform endpoint security with detection and response capabilities. Built by Microsoft. **ThreatDown Endpoint Detection & Response**: EDR solution for workstations and servers with attack detection capabilities. Built by ThreatDown by Malwarebytes. The table above shows where their features, integrations, deployment and company size fit differ. ### Who makes Microsoft Defender for Endpoint and ThreatDown Endpoint Detection & Response? **Microsoft Defender for Endpoint** is made by Microsoft. **ThreatDown Endpoint Detection & Response** is made by ThreatDown by Malwarebytes. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit. ### Is Microsoft Defender for Endpoint a good alternative to ThreatDown Endpoint Detection & Response? Often, yes. Microsoft Defender for Endpoint and ThreatDown Endpoint Detection & Response are both Endpoint Detection and Response products, and both cover Ransomware Prevention. Use the table above to see where features, deployment and company size fit differ. ## Related comparisons - [Microsoft Defender for Endpoint vs Huawei HiSec Endpoint](https://cybersectools.com/compare/huawei-hisec-endpoint-vs-microsoft-defender-for-endpoint) - [Microsoft Defender for Endpoint vs Spharaka EdgeProtect™](https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-spharaka-edgeprotecttm) - [Microsoft Defender for Endpoint vs Sophos EDR](https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-sophos-intercept-x) - [ThreatDown Endpoint Detection & Response vs Huawei HiSec Endpoint](https://cybersectools.com/compare/threatdown-endpoint-detection-and-response-vs-huawei-hisec-endpoint) - [ThreatDown Endpoint Detection & Response vs Spharaka EdgeProtect™](https://cybersectools.com/compare/spharaka-edgeprotecttm-vs-threatdown-endpoint-detection-and-response) - [ThreatDown Endpoint Detection & Response vs Sophos EDR](https://cybersectools.com/compare/sophos-intercept-x-vs-threatdown-endpoint-detection-and-response) ## Alternatives to each - [See all Microsoft Defender for Endpoint alternatives](https://cybersectools.com/alternatives/microsoft-defender-for-endpoint) - [See all ThreatDown Endpoint Detection & Response alternatives](https://cybersectools.com/alternatives/threatdown-endpoint-detection-and-response) --- Source: https://cybersectools.com/compare/microsoft-defender-for-endpoint-vs-threatdown-endpoint-detection-and-response For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/microsoft-defender-for-endpoint.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md. More on Microsoft Defender for Endpoint and ThreatDown Endpoint Detection & Response: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md