# ESET PROTECT vs OPSWAT MetaDefender Endpoint: side-by-side comparison (2026)

[ESET PROTECT](https://cybersectools.com/tools/eset-protect) is a commercial [endpoint protection platform](https://cybersectools.com/categories/epp) solution by [Lockbits](https://cybersectools.com/companies/lockbits). [OPSWAT MetaDefender Endpoint](https://cybersectools.com/tools/opswat-metadefender-endpoint) is a commercial [endpoint protection platform](https://cybersectools.com/categories/epp) solution by [OPSWAT](https://cybersectools.com/companies/opswat). Features, integrations, deployment and the company behind each one, side by side.

## Side-by-side comparison

| | ESET PROTECT | OPSWAT MetaDefender Endpoint |
|---|---|---|
| Pricing model | Commercial | Commercial |
| Category | Endpoint Protection Platform | Endpoint Protection Platform |
| Verified | No | No |
| Deployment type | Hybrid | On-Premises |
| Company size fit | SMB, Mid-Market, Enterprise | Mid-Market, Enterprise |
| Company | Lockbits | OPSWAT |
| Headquarters | – | – |

### Use cases and capabilities

| | ESET PROTECT | OPSWAT MetaDefender Endpoint |
|---|---|---|
| Ransomware Prevention | Yes | – |
| Sandbox | Yes | Yes |
| Encryption | Yes | – |
| Botnet | Yes | – |
| Network Protection | Yes | – |
| Windows Security | Yes | – |
| Zero Day | Yes | – |
| Rootkit | Yes | – |
| USB | – | Yes |

### Core features

**ESET PROTECT**

10 features listed. Sign in on the page to see them.

**OPSWAT MetaDefender Endpoint**

10 features listed. Sign in on the page to see them.

### Integrations

**ESET PROTECT**

No integrations listed.

**OPSWAT MetaDefender Endpoint**

3 integrations listed. Sign in on the page to see them.

## Which one fits you

Based on what each listing shows: deployment, company size, price and open source.

- [ESET PROTECT](https://cybersectools.com/tools/eset-protect) fits if you need both cloud and on-premises options and you are a small business.
- [OPSWAT MetaDefender Endpoint](https://cybersectools.com/tools/opswat-metadefender-endpoint) fits if you need to run it on your own servers.

## ESET PROTECT vs OPSWAT MetaDefender Endpoint FAQ

Common questions when comparing ESET PROTECT vs OPSWAT MetaDefender Endpoint for endpoint protection platform.

### What is the difference between ESET PROTECT and OPSWAT MetaDefender Endpoint?

**ESET PROTECT**: Multi-tier endpoint protection platform with EDR, sandboxing. Built by Lockbits.

**OPSWAT MetaDefender Endpoint**: Protects endpoints from peripheral and removable media threats with multiscanning. Built by OPSWAT.

The table above shows where their features, integrations, deployment and company size fit differ.

### Who makes ESET PROTECT and OPSWAT MetaDefender Endpoint?

**ESET PROTECT** is made by Lockbits. **OPSWAT MetaDefender Endpoint** is made by OPSWAT. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.

### Is ESET PROTECT a good alternative to OPSWAT MetaDefender Endpoint?

Often, yes. ESET PROTECT and OPSWAT MetaDefender Endpoint are both Endpoint Protection Platform products, and both cover Sandbox. Use the table above to see where features, deployment and company size fit differ.

## Related comparisons

- [ESET PROTECT vs Bkav Pro](https://cybersectools.com/compare/bkav-pro-vs-eset-protect)
- [ESET PROTECT vs Cyemptive ZeroStrike](https://cybersectools.com/compare/cyemptive-zerostrike-vs-eset-protect)
- [ESET PROTECT vs Ivanti Neurons for App Control](https://cybersectools.com/compare/eset-protect-vs-ivanti-neurons-for-app-control)
- [OPSWAT MetaDefender Endpoint vs Bkav Pro](https://cybersectools.com/compare/bkav-pro-vs-opswat-metadefender-endpoint)
- [OPSWAT MetaDefender Endpoint vs Cyemptive ZeroStrike](https://cybersectools.com/compare/cyemptive-zerostrike-vs-opswat-metadefender-endpoint)
- [OPSWAT MetaDefender Endpoint vs Ivanti Neurons for App Control](https://cybersectools.com/compare/ivanti-neurons-for-app-control-vs-opswat-metadefender-endpoint)

## Alternatives to each

- [See all ESET PROTECT alternatives](https://cybersectools.com/alternatives/eset-protect)
- [See all OPSWAT MetaDefender Endpoint alternatives](https://cybersectools.com/alternatives/opswat-metadefender-endpoint)

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Source: https://cybersectools.com/compare/eset-protect-vs-opswat-metadefender-endpoint

For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/eset-protect.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md.

More on ESET PROTECT and OPSWAT MetaDefender Endpoint: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md