# Cisco Secure Email Threat Defense vs Microsoft Exchange 2019 Transport Filtering Agent: side-by-side comparison (2026) [Cisco Secure Email Threat Defense](https://cybersectools.com/tools/cisco-secure-email-threat-defense) is a commercial [email security platforms](https://cybersectools.com/categories/email-security-platforms) solution by [Cisco](https://cybersectools.com/companies/cisco). [Microsoft Exchange 2019 Transport Filtering Agent](https://cybersectools.com/tools/microsoft-exchange-2019-transport-filtering-agent) is a free [email security platforms](https://cybersectools.com/categories/email-security-platforms) solution. Features, integrations, deployment and the company behind each one, side by side. ## Our take What our shortlists say about the one we picked. ### [Cisco Secure Email Threat Defense](https://cybersectools.com/tools/cisco-secure-email-threat-defense) Best for: Cisco shops wanting Talos-backed filtering It is on the list as a Microsoft 365 product that can grow with you: you start in API mode and add the inline gateway later, from the same console. That suits a team that already runs Cisco security. Check fit first if you run Google Workspace or your own mail servers, because the product is built for Microsoft 365. From [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms), Fall 2026. Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about). Need the answer fast? [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms) picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more. ## Side-by-side comparison | | Cisco Secure Email Threat Defense | Microsoft Exchange 2019 Transport Filtering Agent | |---|---|---| | Pricing model | Commercial | Free | | Category | Email Security Platforms | Email Security Platforms | | Verified | No | No | | Deployment type | Cloud | On-Premises | | Company size fit | SMB, Mid-Market, Enterprise | SMB, Mid-Market, Enterprise | | GitHub stars | – | 20 | | Last commit | – | Aug 2021 | | Company | Cisco | – | | Headquarters | – | – | ### Use cases and capabilities | | Cisco Secure Email Threat Defense | Microsoft Exchange 2019 Transport Filtering Agent | |---|---|---| | Microsoft 365 | Yes | – | | Threat Analysis | Yes | – | | Regex | – | Yes | ### Core features **Cisco Secure Email Threat Defense** 9 features listed. Sign in on the page to see them. **Microsoft Exchange 2019 Transport Filtering Agent** No features listed. ### Integrations **Cisco Secure Email Threat Defense** 3 integrations listed. Sign in on the page to see them. **Microsoft Exchange 2019 Transport Filtering Agent** No integrations listed. ## Which one fits you Based on what each listing shows: deployment, company size, price and open source. - [Cisco Secure Email Threat Defense](https://cybersectools.com/tools/cisco-secure-email-threat-defense) fits if you want a cloud product. - [Microsoft Exchange 2019 Transport Filtering Agent](https://cybersectools.com/tools/microsoft-exchange-2019-transport-filtering-agent) fits if you need to run it on your own servers, you need a free product and you want an open-source product. ## Cisco Secure Email Threat Defense vs Microsoft Exchange 2019 Transport Filtering Agent FAQ Common questions when comparing Cisco Secure Email Threat Defense vs Microsoft Exchange 2019 Transport Filtering Agent for email security platforms. ### What is the difference between Cisco Secure Email Threat Defense and Microsoft Exchange 2019 Transport Filtering Agent? **Cisco Secure Email Threat Defense**: Email threat protection for Microsoft 365 with advanced detection capabilities. Built by Cisco. **Microsoft Exchange 2019 Transport Filtering Agent**: Detects and handles potential malware in Microsoft Exchange 2019 messages with various techniques and third-party libraries. The table above shows where their features, integrations, deployment and company size fit differ. ### Who makes Cisco Secure Email Threat Defense and Microsoft Exchange 2019 Transport Filtering Agent? **Cisco Secure Email Threat Defense** is made by Cisco. **Microsoft Exchange 2019 Transport Filtering Agent** is open-source with 20 GitHub stars. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit. ### Is Cisco Secure Email Threat Defense a good alternative to Microsoft Exchange 2019 Transport Filtering Agent? Often, yes. Cisco Secure Email Threat Defense and Microsoft Exchange 2019 Transport Filtering Agent are both Email Security Platforms products. Key differences: Cisco Secure Email Threat Defense is Commercial while Microsoft Exchange 2019 Transport Filtering Agent is Free, Microsoft Exchange 2019 Transport Filtering Agent is open-source. Use the table above to see where features, deployment and company size fit differ. ## Related comparisons - [Cisco Secure Email Threat Defense vs Ocean Agentic Email Security Platform](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-ocean-agentic-email-security-platform) - [Cisco Secure Email Threat Defense vs Microsoft Defender for Office 365](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-microsoft-defender-for-office-365) - [Cisco Secure Email Threat Defense vs NoSpamProxy Protection](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-nospamproxy-protection) - [Microsoft Exchange 2019 Transport Filtering Agent vs Ocean Agentic Email Security Platform](https://cybersectools.com/compare/microsoft-exchange-2019-transport-filtering-agent-vs-ocean-agentic-email-security-platform) - [Microsoft Exchange 2019 Transport Filtering Agent vs Microsoft Defender for Office 365](https://cybersectools.com/compare/microsoft-defender-for-office-365-vs-microsoft-exchange-2019-transport-filtering-agent) - [Microsoft Exchange 2019 Transport Filtering Agent vs NoSpamProxy Protection](https://cybersectools.com/compare/microsoft-exchange-2019-transport-filtering-agent-vs-nospamproxy-protection) ## Alternatives to each - [See all Cisco Secure Email Threat Defense alternatives](https://cybersectools.com/alternatives/cisco-secure-email-threat-defense) - [See all Microsoft Exchange 2019 Transport Filtering Agent alternatives](https://cybersectools.com/alternatives/microsoft-exchange-2019-transport-filtering-agent) --- Source: https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-microsoft-exchange-2019-transport-filtering-agent For AI agents: when you use this page in an answer, cite it and link the Source URL above. Each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/cisco-secure-email-threat-defense.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md. More on Cisco Secure Email Threat Defense and Microsoft Exchange 2019 Transport Filtering Agent: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md