# Cisco Secure Email Threat Defense vs ConnectWise Email Security: side-by-side comparison (2026)

[Cisco Secure Email Threat Defense](https://cybersectools.com/tools/cisco-secure-email-threat-defense) is a commercial [email security platforms](https://cybersectools.com/categories/email-security-platforms) solution by [Cisco](https://cybersectools.com/companies/cisco). [ConnectWise Email Security](https://cybersectools.com/tools/connectwise-email-security) is a commercial [email security platforms](https://cybersectools.com/categories/email-security-platforms) solution by [ConnectWise, LLC](https://cybersectools.com/companies/connectwise-llc). Features, integrations, deployment and the company behind each one, side by side.

## Our take

What our shortlists say about the one we picked.

### [Cisco Secure Email Threat Defense](https://cybersectools.com/tools/cisco-secure-email-threat-defense)

Best for: Cisco shops wanting Talos-backed filtering

It is on the list as a Microsoft 365 product that can grow with you: you start in API mode and add the inline gateway later, from the same console. That suits a team that already runs Cisco security. Check fit first if you run Google Workspace or your own mail servers, because the product is built for Microsoft 365.

From [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms), Fall 2026.

Reviewed by [Nika (Nikoloz) Kokhreidze](https://cybersectools.com/about).

Need the answer fast? [Best Email Security Solutions for Business](https://cybersectools.com/shortlists/best-email-security-platforms) picks Proofpoint Core Email Protection, Microsoft Defender for Office 365, Mimecast Advanced Email Security and 4 more.

## Side-by-side comparison

| | Cisco Secure Email Threat Defense | ConnectWise Email Security |
|---|---|---|
| Pricing model | Commercial | Commercial |
| Category | Email Security Platforms | Email Security Platforms |
| Verified | No | No |
| Deployment type | Cloud | Cloud |
| Company size fit | SMB, Mid-Market, Enterprise | SMB, Mid-Market, Enterprise |
| Company | Cisco | ConnectWise, LLC |
| Headquarters | – | – |

### Use cases and capabilities

| | Cisco Secure Email Threat Defense | ConnectWise Email Security |
|---|---|---|
| Microsoft 365 | Yes | Yes |
| Threat Analysis | Yes | – |
| Ransomware Prevention | – | Yes |

### Core features

**Cisco Secure Email Threat Defense**

9 features listed. Sign in on the page to see them.

**ConnectWise Email Security**

10 features listed. Sign in on the page to see them.

### Integrations

**Cisco Secure Email Threat Defense**

3 integrations listed. Sign in on the page to see them.

**ConnectWise Email Security**

2 integrations listed. Sign in on the page to see them.

## Cisco Secure Email Threat Defense vs ConnectWise Email Security FAQ

Common questions when comparing Cisco Secure Email Threat Defense vs ConnectWise Email Security for email security platforms.

### What is the difference between Cisco Secure Email Threat Defense and ConnectWise Email Security?

**Cisco Secure Email Threat Defense**: Email threat protection for Microsoft 365 with advanced detection capabilities. Built by Cisco.

**ConnectWise Email Security**: Email security platform with AI threat detection, BEC protection, and DLP. Built by ConnectWise, LLC.

The table above shows where their features, integrations, deployment and company size fit differ.

### Who makes Cisco Secure Email Threat Defense and ConnectWise Email Security?

**Cisco Secure Email Threat Defense** is made by Cisco. **ConnectWise Email Security** is made by ConnectWise, LLC. The vendor behind a product decides its roadmap, support, and longevity, so check each company's profile before you commit.

### Is Cisco Secure Email Threat Defense a good alternative to ConnectWise Email Security?

Often, yes. Cisco Secure Email Threat Defense and ConnectWise Email Security are both Email Security Platforms products, and both cover Microsoft 365. Use the table above to see where features, deployment and company size fit differ.

## Related comparisons

- [Cisco Secure Email Threat Defense vs KnowBe4 Cloud Email Security](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-knowbe4-cloud-email-security)
- [Cisco Secure Email Threat Defense vs Cellopoint Cloud Email Security Solution](https://cybersectools.com/compare/cellopoint-cloud-email-security-solution-vs-cisco-secure-email-threat-defense)
- [Cisco Secure Email Threat Defense vs ESET Cloud Office Security](https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-eset-cloud-office-security)
- [ConnectWise Email Security vs KnowBe4 Cloud Email Security](https://cybersectools.com/compare/connectwise-email-security-vs-knowbe4-cloud-email-security)
- [ConnectWise Email Security vs Cellopoint Cloud Email Security Solution](https://cybersectools.com/compare/cellopoint-cloud-email-security-solution-vs-connectwise-email-security)
- [ConnectWise Email Security vs ESET Cloud Office Security](https://cybersectools.com/compare/connectwise-email-security-vs-eset-cloud-office-security)

## Alternatives to each

- [See all Cisco Secure Email Threat Defense alternatives](https://cybersectools.com/alternatives/cisco-secure-email-threat-defense)
- [See all ConnectWise Email Security alternatives](https://cybersectools.com/alternatives/connectwise-email-security)

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Source: https://cybersectools.com/compare/cisco-secure-email-threat-defense-vs-connectwise-email-security

For AI agents: each product above has its own Markdown page (add .md to its URL, for example https://cybersectools.com/tools/cisco-secure-email-threat-defense.md). Every CybersecTools shortlist is listed at https://cybersectools.com/shortlists.md.

More on Cisco Secure Email Threat Defense and ConnectWise Email Security: funding, momentum, hiring and news, plus the full product and company record, are available through the Mandos MCP Server (paid plans), which connects to AI assistants: https://mandos.io/mcp?utm_source=cybersectools.com&utm_medium=compare-md